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Taxonomic group: bacteria / Firmicutes (Phylum: Firmicutes)
Host organism: Bos taurus
Associated disease: mastitis [ICD11: GB21.Z

]; infection due to Streptococcus agalactiae [ICD11: XN0KC

]; infection due to Streptococcus [ICD11: XN3NM

]

NCBI PubMed ID: 30873933
Publication DOI: 10.1128/microbiolspec.GPP3-0001-2017
Journal NLM ID: 101634614
Publisher: Washington, DC: ASM Press
Correspondence: Lawrence C. Paoletti <lawrence_paoletti

hms.harvard.edu>
Institutions: Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115

The surface of the Gram-positive opportunistic pathogen Streptococcus agalactiae, or group B Streptococcus (GBS), harbors several carbohydrate and protein antigens with the potential to be effective vaccines. Capsular polysaccharides of all clinically-relevant GBS serotypes coupled to immunogenic proteins of both GBS and non-GBS origin have undergone extensive testing in animals that led to advanced clinical trials in healthy adult women. In addition, GBS proteins either alone or in combination have been tested in animals; a fusion protein construct has recently advanced to human clinical studies. Given our current understanding of the antigenicity and immunogenicity of the wide array of GBS surface antigens, formulations now exist for the generation of viable vaccines against diseases caused by GBS.

structure, capsular polysaccharides, group B Streptococcus, surface, vaccines, Streptococcus agalactiae, Gram-positive

Structure type: fragment of a bigger structure
Location inside paper: fig. 1, oligosaccharide A
Compound class: cell wall polysaccharide
Contained glycoepitopes: IEDB_114708,IEDB_133754,IEDB_135813,IEDB_136105,IEDB_136906,IEDB_137340,IEDB_137472,IEDB_141794,IEDB_141807,IEDB_144826,IEDB_151528,IEDB_151531,IEDB_190606,IEDB_225177,IEDB_885823,SB_7

Comments, role: review; fragment of the proposed structure; The group B carbohydrate is a cell wall-associated molecule common to all strains and serotypes of GBS.

Related record ID(s): 2235, 2236, 2237
NCBI Taxonomy refs (TaxIDs): 1311, 1319
Show glycosyltransferases

There is only one chemically distinct structure:

CC(=O)N[C@H]1[C@H](O[C@H]2[C@H](C)O[C@@H](O[C@H]3[C@@H](O)[C@@H](CO)O[C@H](O[C@H]4[C@H](O)[C@@H](CO)O[C@@H](O[C@H]5[C@H](C)O[C@@H](O[C@H]6[C@@H](O)[C@@H](CO)O[C@H](O[C@H]7[C@H](O)[C@@H](CO)O[C@@H](O[C@H]8[C@H](C)O[C@@H](O[C@H]9[C@H](OC[C@H](O)[C@@H](O[C@@H]%10O[C@@H](C)[C@H](O)[C@@H](O)[C@H]%10O)[C@H](O)[C@H](O)CO)O[C@@H](C)[C@H](O)[C@H]9O)[C@H](O)[C@@H]8O)[C@@H]7NC(C)=O)[C@@H]6O)[C@H](O)[C@@H]5O)[C@@H]4NC(C)=O)[C@@H]3O)[C@H](O)[C@@H]2O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1O[C@H](CO)[C@H](O)[C@H](O[C@@H]2O[C@@H](C)[C@H](O)[C@@H](O)[C@H]2O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O[C@H]4O[C@H](CO)[C@H](O)[C@H](O[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@H]4O)[C@H]3NC(C)=O)[C@@H](O)[C@H]2O)[C@H]1O

SVG MW SMILES 3D mol Ionize

Warning = sub-repeat ending at bDGlcpN: unknown unit count was assumed to be 3