Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Host organism: Homo sapiens
Associated disease: meningitis [ICD11:
1D01 
];
septicemia [ICD11:
MA15.Y ];
infection due to Neisseria meningitidis [ICD11:
XN1DV ]
NCBI PubMed ID: 34579258Publication DOI: 10.3390/vaccines9091021Journal NLM ID: 101629355Publisher: Basel, Switzerland: MDPI AG
Correspondence: Pumtiwitt.McCarthy
morgan.edu
Institutions: Department of Chemistry, Morgan State University, Baltimore, MD, USA, Bioenvironmental Sciences Program, Morgan State University, Baltimore, MD, USA
Vaccines are important in preventing disease outbreaks and controlling the spread of disease in a population. A variety of vaccines exist, including subunit, recombinant, and conjugate vaccines. Glycoconjugate vaccines have been an important tool to fight against diseases caused by a number of bacteria. Glycoconjugate vaccines are often heterogeneous. Vaccines of the future are becoming more rationally designed to have a defined oligosaccharide chain length and position of conjugation. Homogenous vaccines could play an important role in assessing the relationship between vaccine structure and immune response. This review focuses on recent advances in the chemoenzymatic production of defined bacterial oligosaccharides for vaccine development with a focus on Neisseria meningitidis and selected WHO-prioritized antibacterial resistant-pathogens. We also provide some perspective on future advances in the chemoenzymatic synthesis of well-defined oligosaccharides.
synthesis, glycoconjugate vaccines, chemoenzymatic synthesis, bacterial pathogens
Structure type: homopolymer
Location inside paper: Fig. 1C
Trivial name: polysialic acid
Compound class: CPS
Contained glycoepitopes: IEDB_136794,IEDB_146100,IEDB_149174,IEDB_150075,IEDB_150759,IEDB_910420,SB_170,SB_171,SB_172,SB_84
Comments, role: review
NCBI Taxonomy refs (TaxIDs): 135720Reference(s) to other database(s): GTC:G76437DD
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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