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Taxonomic group: bacteria / Proteobacteria (Phylum: Proteobacteria)
Associated disease: infection due to Campylobacter jejuni [ICD11: XN4Q5

]

Publication DOI: 10.2220/biomedres.13.451
Journal NLM ID: 9102548
Publisher: Aligarh, India: Scientific Publishers of India
Institutions: Department of Neurology, Faculty of Medicine, Tokyo Medical and Dental University, Japan

We investigated the lipopolysaccharide (LPS) from Penner's serotype 19 (PEN 19) of C. jejuni that had been isolated from a patient with the Guillain-Barre syndrome (GBS). The LPS was extracted from the bacterium and separated by a silica beads column chromatography. One homogeneous fraction showing reactivity with the patient's serum, rabbit anti-G(M1) antibody, and also with cholera toxin, which binds oligosaccharide of G(M1), was obtained. By gas-liquid chromatography-mass spectrometric analysis, the purified LPS was found to contain D-galactose, D-glucose, N-acetyl-D-galactosamine, N-acetyl-D-glucosamine, N-acetylneuraminic acid; 3-deoxy-2-octulosonic acid, heptose and fatty acids (3-hydroxy-myristic acid and palmitic acid). The result indicates that sugar components of the G(M1)-oligosaccharide are present in the purified LPS. Chemical analysis and immunological binding experiment show that the LPS from C. jejuni (PEN 19) has the oligosaccharide structure in common with G(M1) ganglioside. These results suggest that some GBS patients associated with anti-G(M1), antibody are caused by an autoimmune mechanism after infection by C.jejuni (PEN 19) which has the G(M1)-oligosaccharide structure.

Structure type: oligomer
Aglycon: rest of molecule
Trivial name: GM1 analog
Compound class: glycolipid
Contained glycoepitopes: IEDB_130648,IEDB_130678,IEDB_130679,IEDB_130683,IEDB_130685,IEDB_134627,IEDB_136044,IEDB_136794,IEDB_137472,IEDB_137473,IEDB_141794,IEDB_142487,IEDB_142488,IEDB_146100,IEDB_146664,IEDB_147450,IEDB_147451,IEDB_149174,IEDB_150933,IEDB_153777,IEDB_153778,IEDB_1625329,IEDB_190606,IEDB_547903,IEDB_983931,SB_116,SB_144,SB_164,SB_165,SB_166,SB_170,SB_171,SB_172,SB_187,SB_192,SB_195,SB_23,SB_24,SB_25,SB_37,SB_39,SB_6,SB_68,SB_7,SB_76,SB_8,SB_84,SB_88,SB_96

NCBI Taxonomy refs (TaxIDs): 197
Reference(s) to other database(s): GTC:G48558GR, GlycomeDB:124
Show glycosyltransferases

There is only one chemically distinct structure:

CC(=O)N[C@@H]1[C@@H](O)C[C@](O[C@H]2[C@@H](O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O[C@@H]4O[C@H](CO)[C@H](O)[C@H](O)[C@H]4O)[C@H]3NC(C)=O)[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]3O)[C@@H]2O)(C(=O)O)O[C@H]1[C@H](O)[C@H](O)CO

SVG MW SMILES 3D mol Ionize