Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: infection due to Escherichia coli [ICD11:
XN6P4 
]
Publication DOI: 10.1139/cjc-2015-0594Journal NLM ID: 0372705Publisher: National Research Council of Canada Canada
Correspondence: Chris Whitfield <cwhitfie
uoguelph.ca>
Institutions: Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON N1G 2W1, Canada
The diverse structures of bacterial glycoconjugates are generally established during the early stages of synthesis by the activities of nucleotide sugar-dependent glycosyltransferases active in the cytoplasm. However, in some cases, further modifications of varying complexity occur after the glycoconjugate is exported to the periplasm. These processes are distinguished by the involvement of polyprenyl monosphosphoryl donors and require glycosyltransferases possessing GT-C folds. Established prototypes are found in modifications of some bacterial lipopolysaccharides, where 4-amino-4-deoxy-l-arabinose is added to lipid A and glucose side branches are used to modify O-antigens. Here we review the current understanding of these systems and describe similarities to other periplasmic glycan modifications in bacteria and the N-glycosylation pathway for assembly of eukaryotic glycoproteins.
LPS, O-antigen, lipid A, glycosyltransferase, glycoconjugate biosynthesis, GT-C enzymes, polyprenol lipid
Structure type: suggested polymer biological repeating unit
Location inside paper: fig.3, E. coli O16
The structure in this paper was incorrect:
Compound class: O-polysaccharide, O-antigen
Contained glycoepitopes: IEDB_130422,IEDB_136095,IEDB_136105,IEDB_137340,IEDB_137472,IEDB_141807,IEDB_142488,IEDB_144998,IEDB_146664,IEDB_151531,IEDB_158539,IEDB_190606,IEDB_225177,IEDB_885823,IEDB_983931,SB_192
Comments, role: (review)
Related record ID(s): 2061, 10218, 20109, 22422, 30068
NCBI Taxonomy refs (TaxIDs): 1010799Reference(s) to other database(s): GTC:G73945FP, GlycomeDB:
25543
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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