Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: infection due to Escherichia coli [ICD11:
XN6P4 
]
The structure was elucidated in this paperNCBI PubMed ID: 1291048Publication DOI: 10.1016/0008-6215(92)85016-sJournal NLM ID: 0043535Publisher: Elsevier
Institutions: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Wroclaw, Poland
Mild acid hydrolysis of Escherichia coli O104 lipopolysaccharide released an O-specific polysaccharide, a tetrasaccharide repeating unit, the corresponding dimer, and a disaccharide fragment of the repeating unit. Complete and incomplete cores, and oligosaccharides comprising fragments of the repeating unit and the core region, were also obtained. On the basis of sugar and methylation analysis, FAB-mass spectrometry and NMR spectroscopy of the hydrolysis products, the repeating unit of the O-specific polysaccharide was shown to be the tetrasaccharide: →4)-α-D-Galp-(1→4)-α-Neup5,7,9Ac3-(2→3)-β-D-Galp-(1→3)-β-D-GalpNAc-(1→. The linkage between the O-specific polysaccharide chain and the core region, which appeared to be of the R2 type, was established. These results indicate that N-acetylneuraminic acid, located in the O-specific polysaccharide, is an inherent lipopolysaccharide component.
Structure type: polymer chemical repeating unit
Location inside paper: abstract, p.197, scheme 1, structure 1
Compound class: O-polysaccharide, O-antigen
Contained glycoepitopes: IEDB_130648,IEDB_134627,IEDB_136044,IEDB_136794,IEDB_136906,IEDB_137472,IEDB_137473,IEDB_141794,IEDB_146100,IEDB_147450,IEDB_149174,IEDB_150933,IEDB_151528,IEDB_190606,SB_116,SB_165,SB_166,SB_170,SB_171,SB_172,SB_187,SB_195,SB_23,SB_24,SB_25,SB_39,SB_68,SB_7,SB_70,SB_8,SB_84,SB_88,SB_97
Methods: 13C NMR, 1H NMR, methylation, NMR-2D, FAB-MS, sugar analysis, GLC, mild acid hydrolysis
Comments, role: published polymerization frame was shifted for conformity with other records
Related record ID(s): 116943
NCBI Taxonomy refs (TaxIDs): 2072453Reference(s) to other database(s): GTC:G18884UL, GlycomeDB:
6316
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There is only one chemically distinct structure:
Found 
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