Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Host organism: Homo sapiens
Associated disease: gastritis [ICD11:
DA42 
];
infection due to Helicobacter pylori [ICD11:
XN3DY ]
NCBI PubMed ID: 27075488Publication DOI: 10.1093/femsre/fuw007Journal NLM ID: 8902526Publisher: Oxford University Press
Correspondence: m.valvano
qub.ac.uk
Institutions: Institute for Bioengineering and Biosciences, Department of Bioengineering, Instituto Superior Tecnico, Universidade de Lisboa, Lisbon, Portugal, Department of Microbiology and Immunology, University of Western Ontario, London, ON, Canada, Centre for Infection and Immunity, Queen's University Belfast, Belfast, UK
The Gram-negative bacterial lipopolysaccharide (LPS) is a major component of the outer membrane that plays a key role in host-pathogen interactions with the innate immune system. During infection, bacteria are exposed to a host environment that is typically dominated by inflammatory cells and soluble factors, including antibiotics, which provide cues about regulation of gene expression. Bacterial adaptive changes including modulation of LPS synthesis and structure are a conserved theme in infections, irrespective of the type or bacteria or the site of infection. In general, these changes result in immune system evasion, persisting inflammation and increased antimicrobial resistance. Here, we review the modifications of LPS structure and biosynthetic pathways that occur upon adaptation of model opportunistic pathogens (Pseudomonas aeruginosa, Burkholderia cepacia complex bacteria, Helicobacter pylori and Salmonella enterica) to chronic infection in respiratory and gastrointestinal sites. We also discuss the molecular mechanisms of these variations and their role in the host-pathogen interaction.
O antigen, Pseudomonas aeruginosa, lipid A, Helicobacter pylori, cystic fibrosis, Burkholderia cenocepacia, adaptive mutation, gastric ulcer
Structure type: oligomer
Location inside paper: p.487, Le(a)
Trivial name: Lewis a antigen Le(a), Lewis a antigen, Lewis A antigen Le(a)
Contained glycoepitopes: IEDB_130653,IEDB_135813,IEDB_136044,IEDB_136045,IEDB_137340,IEDB_137472,IEDB_1391962,IEDB_141794,IEDB_141807,IEDB_142078,IEDB_142489,IEDB_143794,IEDB_144562,IEDB_149556,IEDB_150899,IEDB_151531,IEDB_152214,IEDB_174333,IEDB_190606,IEDB_423096,IEDB_461723,SB_137,SB_155,SB_165,SB_166,SB_187,SB_195,SB_29,SB_7,SB_86,SB_88
Comments, role: review; type 1 Lewis antigen
Related record ID(s): 12180, 12181, 12182, 12183
NCBI Taxonomy refs (TaxIDs): 210Reference(s) to other database(s): GTC:G39023AU
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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