Taxonomic group: bacteria / Firmicutes
(Phylum: Firmicutes)
Associated disease: infection due to Bacillus subtilis [ICD11:
XM4SG9 
]
NCBI PubMed ID: 6919863Publication DOI: 10.1007/82_2015_5021Publisher: Cham: Springer.
Editors: Bagnoli F, Rappuoli R
Correspondence: suzanne_walker
hms.harvard.edu
Institutions: Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, 02138, USA
Gram-positive organisms, including the pathogens Staphylococcus aureus, Streptococcus pneumoniae, and Enterococcus faecalis, have dynamic cell envelopes that mediate interactions with the environment and serve as the first line of defense against toxic molecules. Major components of the cell envelope include peptidoglycan (PG), which is a well-established target for antibiotics, teichoic acids (TAs), capsular polysaccharides (CPS), surface proteins, and phospholipids. These components can undergo modification to promote pathogenesis, decrease susceptibility to antibiotics and host immune defenses, and enhance survival in hostile environments. This chapter will cover the structure, biosynthesis, and important functions of major cell envelope components in gram-positive bacteria. Possible targets for new antimicrobials will be noted.
biosynthesis, structure, capsular polysaccharide, teichoic acid, phospholipids, peptidoglycan (PG), surface proteins
Structure type: polymer chemical repeating unit ; n= 5000
Location inside paper: fig.2
Trivial name: peptidoglycan (PG)
Contained glycoepitopes: IEDB_135813,IEDB_137340,IEDB_141807,IEDB_151531,IEDB_1635957,IEDB_241115,IEDB_423183,IEDB_885814
Comments, role: review
NCBI Taxonomy refs (TaxIDs): 1423
Show glycosyltransferases
There are too many chemically distinct structures (~288), so only one is shown:
-4)[Ac(1-2)]bDGlcpN(1-4)[xDAla?(1-2)xDAla?(1-2)xXmPmN2?(1-2)x?Gln?(1-1)x?Ala?(2-8),Ac(1-2)]bXMurp(1-
Found 
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