Ekpo P, Nano FE Arg276 of GseA, a Chlamydia trachomatis Kdo transferase, is required for the synthesis of the chlamydial genus-specific epitope in Escherichia coli FEMS Microbiology Letters96 (1992)
49-54
NCBI PubMed ID:1382035 Journal NLM ID:7705721 Publisher: Blackwell Publishing Institutions: Canadian Bacterial Disease Network, University of Victoria, British Columbia, Canada
GseA is an enzyme from Chlamydia trachomatis that can catalyse the addition of three 3-deoxy-D-manno-octulosonic acid (Kdo) residues onto lipid A precursors. GseA is similar, and in a few stretches identical, in its amino acid sequence to KdtA, an Escherichia coli Kdo transferase. In this study we altered an amino acid of GseA in a region that is identical between GseA and KdtA to test its importance in the structure or catalytic activity of GseA. We found that when Arg276 was changed to Lys, Ile or Ser, GseA activity was lost, suggesting an enzymatic role for this amino acid residue.
Related record ID(s): 147530 NCBI Taxonomy refs (TaxIDs):813 Reference(s) to other database(s): GTC:G00192PV, GlycomeDB:37977 Show glycosyltransferases
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