Found 1 structure.
Displayed structure 1
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1. Compound ID: 12890
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/Variants 0/-a-Neup5Ac-(2-3)-b-D-Galp-(1-3)-b-D-GlcpNAc-(1-3)-+
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-4)-b-D-Glcp-(1-4)-b-D-Galp-(1-
/Variants 0/ is:
?%Ac-9)-
OR (exclusively)
?%Ac-8)-
OR (exclusively)
?%Ac-7)- |
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Structure type: polymer chemical repeating unit
Compound class: CPS
Contained glycoepitopes: IEDB_117715,IEDB_135813,IEDB_136044,IEDB_136794,IEDB_137340,IEDB_137472,IEDB_1391962,IEDB_1391966,IEDB_141589,IEDB_141794,IEDB_141807,IEDB_142076,IEDB_142078,IEDB_142351,IEDB_142487,IEDB_142488,IEDB_143794,IEDB_146100,IEDB_146664,IEDB_149174,IEDB_150899,IEDB_150933,IEDB_151531,IEDB_157001,IEDB_190606,IEDB_241109,IEDB_241110,IEDB_910422,IEDB_983931,SB_116,SB_124,SB_127,SB_133,SB_137,SB_145,SB_156,SB_165,SB_166,SB_170,SB_171,SB_172,SB_173,SB_174,SB_186,SB_187,SB_192,SB_195,SB_29,SB_39,SB_6,SB_68,SB_7,SB_84,SB_88
The structure is contained in the following publication(s):
- Article ID: 5129
Berti F, De Ricco R, Rappuoli R "Role of O-Acetylation in the Immunogenicity of Bacterial Polysaccharide Vaccines" -
Molecules 23(6) (2018) 1340
The incidence of infectious diseases caused by several bacterial pathogens such as Haemophilus influenzae type b, Streptococcus pneumoniae, and Neisseria meningitidis, has been dramatically reduced over the last 25 years through the use of glycoconjugate vaccines. The structures of the bacterial capsular polysaccharide (CPS) antigens, extracted and purified from microbial cultures and obtained with very high purity, show that many of them are decorated by O-acetyl groups. While these groups are often considered important for the structural identity of the polysaccharides, they play a major role in the functional immune response to some vaccines such as meningococcal serogroup A and Salmonella typhi Vi, but do not seem to be important for many others, such as meningococcal serogroups C, W, Y, and type III Group B Streptococcus. This review discusses the O-acetylation status of CPSs and its role in the immunological responses of these antigens.
O-acetylation, Bacterial polysaccharide, conjugate vaccines, Bacterial Vaccines, carbohydrate antigens
NCBI PubMed ID: 29865239Publication DOI: 10.3390/molecules23061340Journal NLM ID: 100964009Publisher: Basel, Switzerland: MDPI
Correspondence: rino.x.rappuoli@gsk.com
Institutions: External R&D, GSK Vaccines, 53100 Siena, Italy, External R&D, GSK Vaccines, 53100 Siena, Ital
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