Taxonomic group: bacteria / Firmicutes
(Phylum: Firmicutes)
Host organism: Homo sapiens
Associated disease: pneumonia [ICD11:
CA40 
];
meningitis [ICD11:
1D01 ];
septicemia [ICD11:
MA15.Y ];
infection due to Streptococcus pneumoniae [ICD11:
XN3PW ]
NCBI PubMed ID: 29333751Publication DOI: 10.1002/chem.201705379Journal NLM ID: 9513783Publisher: Weinheim: VCH Verlagsgesellschaft/Verlag I
Correspondence: peter.seeberger
mpikg.mpg.de
Institutions: University of Chemistry and Technology, Prague, Department of Organic Chemistry, Technicka 5, 16000, Praha 6, CZECH REPUBLIC, Max Planck Institute of Colloids and Interfaces, Biomolecular Systems, Am Muhlenberg 1, Research Campus Golm, 14476, Potsdam, GERMANY
Streptococcus pneumoniae causes life-threatening diseases including meningitis, pneumonia and sepsis. Existing glycoconjugate vaccines based on purified capsular polysaccharides are widely used and help to prevent millions of deaths every year. Here, we report total synthesis of oligosaccharides resembling portions of the S. pneumoniae serotype 7F (ST7F) capsular polysaccharide repeating unit. To define minimal glycan epitopes, glycan microarrays containing the synthetic oligosaccharides were used to screen human reference serum and revealed that both side chains of the ST7F play a key role in antigen recognition. The identification of protective minimal epitopes is vital to design efficient semi- and fully-synthetic glycoconjugate vaccines.
Streptococcus pneumoniae, total synthesis, Glycan arrays, minimal glycotopes, serotype 7F
Structure type: polymer chemical repeating unit
Location inside paper: fig.1, compound 1
Trivial name: glycan epitope (glycotope)
Compound class: CPS
Contained glycoepitopes: IEDB_130648,IEDB_136044,IEDB_136105,IEDB_136906,IEDB_137340,IEDB_137472,IEDB_137473,IEDB_141794,IEDB_141807,IEDB_142488,IEDB_146664,IEDB_151528,IEDB_151531,IEDB_190606,IEDB_225177,IEDB_885823,IEDB_983931,SB_165,SB_166,SB_187,SB_192,SB_195,SB_7,SB_88
Methods: 13C NMR, 1H NMR, NMR-2D, TLC, chemical synthesis, chemical methods, FTIR, glycosylation
NCBI Taxonomy refs (TaxIDs): 1313Reference(s) to other database(s): GTC:G24963GX, GlycomeDB:
16860
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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