Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: infection due to Campylobacter jejuni [ICD11:
XN4Q5 
]
NCBI PubMed ID: 8330896Publication DOI: 10.1016/S0171-2985(11)80338-4Journal NLM ID: 8002742Publisher: Amsterdam: Elsevier
Institutions: Forschungsinstitut Borstel, Institut für Experimentelle Biologie und Medizin, Germany, Osaka University, Faculty of Science, Dept. of Chemistry, Osaka, Japan
Lipopolysaccharides (LPS) constitute the O-antigens and endotoxins of Gram-negative bacteria. Whereas both the polysaccharide and lipid portion of LPS contribute to the pathogenic potential of this class of bacteria, it is the lipid component (lipid A) which determines the endotoxic properties of LPS. The primary structure of lipid A of various bacterial origin has been elucidated and Escherichia coli lipid A has been chemically synthesized. The biological analysis of synthetic lipid A partial structures proved that the expression of endotoxic activity depends on a unique structural arrangement and conformation. Such analyses have furthermore provided insight into the determinants required for lipid A binding to and activation of human target cells. Present research efforts aim at the molecular characterization of the specificity, modulation and biomedical consequences of the interaction of lipid A with host cells.
Structure type: oligomer
Location inside paper: fig. 3
Compound class: lipid A, glycolipid
Contained glycoepitopes: IEDB_141181,IEDB_141807,IEDB_151531
Comments, role: review
Related record ID(s): 129872, 129874, 129876, 129877
NCBI Taxonomy refs (TaxIDs): 197
Show glycosyltransferases
There is only one chemically distinct structure:
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