Taxonomic group: plant / Streptophyta
(Phylum: Streptophyta)
Organ / tissue: flower
NCBI PubMed ID: 8158164Publication DOI: 10.1021/np50103a006Journal NLM ID: 7906882Publisher: American Society of Pharmacognosy
Institutions: Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill 27599
An active anti-HIV principle, acacetin-7-O-β-D-galactopyranoside, has been isolated from Chrysanthemum morifolium. Seven additional flavonoids isolated from this plant, 13 known related flavonoids, and 14 synthetic flavonoids were also evaluated as inhibitors of HIV replication in H9 cells. A known flavone, chrysin, was found to be the most promising compound in this series. Flavonoids with hydroxy groups at C-5 and C-7 and with a C-2-C-3 double bond were more potent inhibitors of HIV growth. In general, the presence of substituents (hydroxyl and halogen) in the B-ring increased toxicity and/or decreased activity.
Structure type: monomer
Location inside paper: 6
Trivial name: glucoluteolin, luteolin 7-glucoside
Compound class: saponin glycoside, glycoside, flavonoid glycoside, flavonol glycoside, flavone glycoside, flavone glucoside
Contained glycoepitopes: IEDB_142488,IEDB_146664,IEDB_613439,IEDB_983931,SB_192
NCBI Taxonomy refs (TaxIDs): 41568Reference(s) to other database(s): CCSD:
50066, CBank-STR:939
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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