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Taxonomic group: bacteria / Proteobacteria (Phylum: Proteobacteria)
Associated disease: infection due to Escherichia coli [ICD11: XN6P4

]

The structure was elucidated in this paper
NCBI PubMed ID: 16462025
Publication DOI: 10.1248/bpb.29.240
Journal NLM ID: 9311984
Publisher: Pharmaceutical Society of Japan
Correspondence: ohnonao

ps.toyaku.ac.jp
Institutions: Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horonouchi, Hachioji, Tokyo 192-0392, Japan, Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan

Candida albicans water soluble fraction (CAWS), water soluble fraction of Candida albicans mainly composed of mannoprotein-β-glucan complex, has various biological effects, such as anaphylactoid shock and coronary arteritis. These toxicological effects fit CAWS as one of PAMPs, pathogen-associated molecular patterns. Acute anaphylactoid reaction is known to be induced by lipopolysaccharide from Escherichia coli O9 (O9 LPS), which possesses the mannose homopolysaccharide as the O-antigen region. In the present study, we compared immunotoxicological and immunochemical similarity between CAWS and O9 LPS. CAWS strongly reacted with Candida serum factors, and the reactivity was found to be partially competed with O9 LPS. CAWS induced lethal toxicity was inhibited by pretreatment of mice with i.v. injection of CAWS. The lethality was found to be inhibited by i.v. injection of O9 LPS. Vice versa, O9 LPS induced acute lethal toxicity was also inhibited by pretreatment of mice with CAWS. These results suggested that CAWS, fungal PAMPs, and O9 LPS from Gram-negative bacteria share, at least in part, immunochemical and immunotoxicological activities.

Lipopolysaccharide, LPS, Bacterial, O-antigen, O antigen, molecular, water, Escherichia coli, complex, induced, mice, bacteria, endotoxin, biological, activity, region, immunochemical, Gram-negative bacteria, toxicity, Japan, similarity, serum, reaction, effect, Mannose, mannan, acute, reactivity, fraction, soluble, fungal, pattern, shock, lethal toxicity, Candida albicans, anaphylactoid shock, pharmacy, immunopharmacology, injection, lethality, LPS-induced

Structure type: polymer chemical repeating unit
Location inside paper: p. 243, fig 3B Escherichia coli O9
Compound class: O-polysaccharide, O-antigen
Contained glycoepitopes: IEDB_115576,IEDB_130701,IEDB_136104,IEDB_137485,IEDB_140116,IEDB_141111,IEDB_141795,IEDB_141830,IEDB_143632,IEDB_144983,IEDB_152206,IEDB_153756,IEDB_164174,IEDB_164175,IEDB_164176,IEDB_164480,IEDB_174840,IEDB_241100,IEDB_76933,IEDB_983930,SB_136,SB_196,SB_197,SB_44,SB_67,SB_72

Methods: serological methods
Biological activity: serological data, biological activity data

Related record ID(s): 20181, 20509, 20510
NCBI Taxonomy refs (TaxIDs): 1010797
Reference(s) to other database(s): GTC:G46886NR
Show glycosyltransferases

There are 2 chemically distinct structures. Please, select:

*O[C@@H]1[C@H](O)[C@@H](O[C@@H]2[C@H](O)[C@@H](O[C@@H]3[C@@H](O[C@@H]4[C@@H](O[C@@H]5C(*)O[C@H](CO)[C@@H](O)[C@@H]5O)O[C@H](CO)[C@@H](O)[C@@H]4O)O[C@H](CO)[C@@H](O)[C@@H]3O)O[C@H](CO)[C@H]2O)O[C@H](CO)[C@H]1O

SVG MW SMILES 3D mol Ionize