Taxonomic group: plant / Streptophyta
(Phylum: Streptophyta)
NCBI PubMed ID: 8364466Journal NLM ID: 9311984WWW link: http://ci.nii.ac.jp/naid/110003640222Publisher: Pharmaceutical Society of Japan
Institutions: Kyoritsu College of Pharmacy, Tokyo, Japan
Controlled Smith degradation of ukonan C, a phagocytosis-activating polysaccharide isolated from the rhizome of Curcuma longa L., was performed. The reticuloendothelial system-potentiating, anti-complementary and alkaline phosphatase-inducing activities of ukonan C and its degradation products were investigated. Methylation analyses of the primary and secondary Smith degradation products and of a de-arabinosylated product indicated that structural features of the arabinogalactan core of ukonan C include a backbone chain composed of β-1,3-linked D-galactose and β-1,4-linked D-xylose. All of the galactose units in the backbone carry side chains composed of β-1,6-linked D-galactosyl residues with or without terminal α-L-arabinose units at position 3. Ukonan C showed remarkable effects on both reticuloendothelial system-potentiating and alkaline phosphatase-inducing activities. Periodate oxidation caused a decrease in or disappearance of the immunological activities, but the controlled Smith degradation product having the arabinogalactan core structure of polysaccharide showed a pronounced effect on anti-complementary activity.
Structure type: polymer chemical repeating unit
Location inside paper: Chart 1, e and f
Contained glycoepitopes: IEDB_136044,IEDB_137472,IEDB_141794,IEDB_153201,IEDB_156489,IEDB_156493,IEDB_156557,IEDB_190606,SB_165,SB_166,SB_187,SB_195,SB_7,SB_88
Methods: partial acid hydrolysis, Smith degradation, biological assays, PAGE, gel chromatography, methylation analysis
Comments, role: structural unit; parent molecule: ukonan C; ID110050 : ID110048 : ID110048 : ID260048 : (ID210048 + ID210048) = 2:1:1:3:3
Related record ID(s): 110048, 110050, 260048
NCBI Taxonomy refs (TaxIDs): 136217Reference(s) to other database(s): GTC:G69386QK, CCSD:
6322, CBank-STR:9836
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There is only one chemically distinct structure:
Found 
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