Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: infection due to Escherichia coli [ICD11:
XN6P4 
]
NCBI PubMed ID: 17400574Publication DOI: 10.1093/molbev/msm058Journal NLM ID: 8501455Publisher: Oxford University Press
Correspondence: reeves
angis.org.au
Institutions: School of Molecular and Microbial Biosciences, University of Sydney, Sydney, New South Wales, 2006, Australia
We have sequenced the O-antigen gene clusters for the Escherichia coli O98 and Yersinia kristensenii O11 O antigens. The basic structures of these O antigens are identical, and the sequence data indicate that Y. kristensenii O11 gained its O antigen gene cluster by lateral gene transfer (LGT). E. coli O98 has a typical O-antigen gene cluster between galF and gnd as is usual in E. coli. However the O-antigen gene cluster of Y. kristensenii O11 is not located at the traditional Yersinia O-antigen gene cluster locus, between hemH and gsk, but at a novel chromosomal locus between aroA and cmk where it is flanked by remnant galF and gnd genes that indicate the probable source of the gene cluster. Phylogenetic analysis indicated that the source was not E. coli itself but a species in the Escherichia, Salmonella and Klebsiella group of genera. Although other O-antigen studies imply LGT on the basis of the hyper-variability of the loci and GC content, this report also identifies a potential donor, and provides evidence for the mechanism involved. Remnant IS sequences flank the galF and gnd remnants and suggest that LGT of the gene cluster was IS mediated
Escherichia coli, O-antigen gene cluster, lateral gene transfer, Yersinia kristensenii
Structure type: suggested polymer biological repeating unit
Location inside paper: p.1356, fig.1A
Compound class: O-polysaccharide, O-antigen
Contained glycoepitopes: IEDB_135813,IEDB_137340,IEDB_141807,IEDB_151531
Methods: SDS-PAGE, genetic methods
Biosynthesis and genetic data: genetic data
Related record ID(s): 20670, 22012, 105861
NCBI Taxonomy refs (TaxIDs): 562,
28152Reference(s) to other database(s): GTC:G15487QC, GlycomeDB:
34691
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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