Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: infection due to Acinetobacter baumannii [ICD11:
XN8LS 
]
NCBI PubMed ID: 37955403Publication DOI: 10.1021/acs.orglett.3c03417Journal NLM ID: 100890393Publisher: American Chemical Society
Correspondence: S.S. Kulkarni <suvarn
chem.iitb.ac.in>
Institutions: Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India
Herein, we report the first total synthesis of conjugation-ready tetrasaccharide repeating units of Acinetobacter baumannii strain 34 and O5 comprising a common disaccharide motif [α-L-FucpNAc-(1→4)-α-D-GalpNAcA]. The installation of 1,2-cis linkages employing a disarmed 2-azido-D-galacturonic acid derivative as the donor is addressed here. The synthesis of the tetrasaccharide repeating units of A. baumannii strain 34 and O5 is accomplished via the longest linear sequences of 19 steps in 9.8% and 21 steps in 8.4% overall yields, respectively.
repeating unit, Acinetobacter baumannii, capsular polysaccharide, O-polysaccharide, total synthesis, A.baumannii 34, A.baumannii O5
Structure type: polymer chemical repeating unit
Location inside paper: p. 8333
Compound class: CPS, O-polysaccharide, O-antigen
Contained glycoepitopes: IEDB_135813,IEDB_137340,IEDB_141807,IEDB_151531
Methods: 13C NMR, 1H NMR, TLC, chemical synthesis, FTIR, glycosylation, optical rotation measurement, CC, HR-ESI-MS
Related record ID(s): 26010, 26011
NCBI Taxonomy refs (TaxIDs): 470Reference(s) to other database(s): GTC:G73635WZ, GlycomeDB:
25208
Show glycosyltransferases
There is only one chemically distinct structure:
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