Taxonomic group: bacteria / Firmicutes
(Phylum: Firmicutes)
Associated disease: septicemia [ICD11:
MA15.Y 
];
infection due to Streptococcus [ICD11:
XN3NM ]
NCBI PubMed ID: 30873933Publication DOI: 10.1128/microbiolspec.GPP3-0001-2017Journal NLM ID: 101634614Publisher: Washington, DC: ASM Press
Correspondence: Lawrence C. Paoletti <lawrence_paoletti
hms.harvard.edu>
Institutions: Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115
The surface of the Gram-positive opportunistic pathogen Streptococcus agalactiae, or group B Streptococcus (GBS), harbors several carbohydrate and protein antigens with the potential to be effective vaccines. Capsular polysaccharides of all clinically-relevant GBS serotypes coupled to immunogenic proteins of both GBS and non-GBS origin have undergone extensive testing in animals that led to advanced clinical trials in healthy adult women. In addition, GBS proteins either alone or in combination have been tested in animals; a fusion protein construct has recently advanced to human clinical studies. Given our current understanding of the antigenicity and immunogenicity of the wide array of GBS surface antigens, formulations now exist for the generation of viable vaccines against diseases caused by GBS.
structure, capsular polysaccharides, group B Streptococcus, surface, vaccines, Streptococcus agalactiae, Gram-positive
Structure type: polymer chemical repeating unit
Location inside paper: fig. 3, GBS type II
Compound class: CPS
Contained glycoepitopes: IEDB_130646,IEDB_130697,IEDB_135813,IEDB_136044,IEDB_136794,IEDB_137340,IEDB_137472,IEDB_137776,IEDB_1391966,IEDB_140108,IEDB_140110,IEDB_140122,IEDB_141794,IEDB_141807,IEDB_142351,IEDB_142487,IEDB_142488,IEDB_146100,IEDB_146664,IEDB_149144,IEDB_149174,IEDB_150933,IEDB_151531,IEDB_153201,IEDB_153218,IEDB_153543,IEDB_156493,IEDB_190606,IEDB_423120,IEDB_983931,SB_115,SB_116,SB_131,SB_145,SB_165,SB_166,SB_170,SB_171,SB_172,SB_173,SB_187,SB_192,SB_195,SB_30,SB_39,SB_6,SB_68,SB_7,SB_84,SB_88
Comments, role: review
NCBI Taxonomy refs (TaxIDs): 1319Reference(s) to other database(s): GTC:G94542ED, GlycomeDB:
15633
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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