Taxonomic group: bacteria / Firmicutes
(Phylum: Firmicutes)
Associated disease: infection due to Streptococcus pneumoniae [ICD11:
XN3PW 
]
NCBI PubMed ID: 30977464Publication DOI: 10.1128/microbiolspec.GPP3-0019-2018Journal NLM ID: 101634614Publisher: Washington, DC: ASM Press
Correspondence: James Patton <James.paton
adelaide.edu.au>
Institutions: Research Centre for Infectious Diseases, Department of Molecular and Biomedical Science, University of Adelaide, Adelaide, 5005, Australia
The polysaccharide capsule of Streptococcus pneumoniae is the dominant surface structure of the organism and plays a critical role in virulence, principally by interfering with host opsonophagocytic clearance mechanisms. The capsule is the target of current pneumococcal vaccines, but there are 98 currently recognised polysaccharide serotypes and protection is strictly serotype-specific. Widespread use of these vaccines is driving changes in serotype prevalence in both carriage and disease. This chapter summarises current knowledge on the role of the capsule and its regulation in pathogenesis, the mechanisms of capsule synthesis, the genetic basis for serotype differences, and provides insights into how so many structurally distinct capsular serotypes have evolved. Such knowledge will inform ongoing refinement of pneumococcal vaccination strategies.
Streptococcus pneumoniae, capsular polysaccharide, gene cluster, function analysis, pneumococcal vaccines
Structure type: polymer biological repeating unit
Location inside paper: fig.1, serotype 6B
Compound class: CPS
Contained glycoepitopes: IEDB_114703,IEDB_136105,IEDB_136906,IEDB_137472,IEDB_141794,IEDB_142488,IEDB_144998,IEDB_146664,IEDB_151528,IEDB_153532,IEDB_153533,IEDB_153534,IEDB_153753,IEDB_158539,IEDB_190606,IEDB_225177,IEDB_591403,IEDB_885823,IEDB_983931,SB_192,SB_7
Comments, role: review
Related record ID(s): 1087
NCBI Taxonomy refs (TaxIDs): 1313Reference(s) to other database(s): GTC:G24508EM
Show glycosyltransferases
There is only one chemically distinct structure:
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