Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria) Host organism: Homo sapiens
Organ / tissue: middle ear Associated disease: acute otitis media [ICD11:
AB00 , Life stage: adult];
infection due to Haemophilus influenzae [ICD11:
XN1P6 ]
The structure was elucidated in this paper NCBI PubMed ID: 18465844 Publication DOI: 10.1021/bi702510b Journal NLM ID: 0370623 Publisher: American Chemical Society
Correspondence: Susanna.Lundstrom
ki.se
Institutions: Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario, Canada, K1A 0R6, Clinical Research Centre, Karolinska Institutet and University College of South Stockholm, Novum, Huddinge, Sweden, Molecular Infectious Diseases Group, University of Oxford, Department of Paediatrics, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, U.K.
We here report the lipopolysaccharide (LPS) structures expressed by nontypeable Haemophilus influenzae R2846, a strain whose complete genome sequence has recently been obtained. Results were obtained by using NMR techniques and ESI-MS on O-deacylated LPS and core oligosaccharide material (OS) as well as ESI-MS (n) on permethylated dephosphorylated OS. A β-D-Glcp-(1→4)-D-α-D-Hepp-(1→6)-β-D-Glcp-(1→4) unit was found linked to the proximal heptose (HepI) of the conserved triheptosyl inner-core moiety, l-α-D-Hepp-(1→2)-[PEtn→6]-L-α-D-Hepp-(1→3)-L-α-D-Hepp-(1→5)-[PPEtn→4]-α-Kdo-(2→6)-lipid A. The β-D-Glcp (GlcI) linked to HepI was also branched with oligosaccharide extensions from O-4 and O-6. O-4 of GlcI was substituted with sialyllacto- N-neotetraose [α-Neu5Ac-(2→3)-β-D-Galp-(1→4)-β-D-GlcpNAc-(1→3)-β-D-Galp-(1→4)-β-D-Glcp-(1→] and the related structure [(PEtn→6)-α-D-GalpNAc-(1→6)-β-D-Galp-(1→4)-β-D-GlcpNAc-(1→3)-β-D-Galp-(1→4)-β-D-Glcp-(1→]. The distal heptose (HepIII) was substituted at O-2 by β-D-Gal. Phosphate, phosphoethanolamine, phosphocholine, acetate, and glycine were found to substitute the core oligosaccharide. Two heptosyltransferase genes, losB1 and losB2, have been identified from the R2846 genome sequence and are candidates to add the noncore heptose to the LPS. Mutant strain R2846 losB1 did not show dd-heptose in the extension from HepI but still contained minor quantities of ld-heptose at the same position, indicating that the losB1 gene is required to add dd-heptose to GlcI. The LPS from strain R2846 losB1/ losB2 expressed no noncore heptose, consistent with losB2 directing the addition of LD-heptose.
Lipopolysaccharide, NMR, Haemophilus influenzae, core oligosaccharide, structural analysis
Structure type: oligomer
Location inside paper: p.6035, chart 3
Aglycon: lipid A
Compound class: LPS
Contained glycoepitopes: IEDB_115009,IEDB_116046,IEDB_120354,IEDB_123890,IEDB_130646,IEDB_130650,IEDB_130697,IEDB_135813,IEDB_136044,IEDB_136794,IEDB_137340,IEDB_137472,IEDB_137776,IEDB_137777,IEDB_137779,IEDB_138949,IEDB_1391966,IEDB_139428,IEDB_140087,IEDB_140088,IEDB_140090,IEDB_140108,IEDB_140110,IEDB_140122,IEDB_140624,IEDB_141794,IEDB_141807,IEDB_142351,IEDB_142487,IEDB_142488,IEDB_146100,IEDB_146664,IEDB_148488,IEDB_149144,IEDB_149174,IEDB_150933,IEDB_151531,IEDB_190606,IEDB_2189046,IEDB_2189047,IEDB_423120,IEDB_983931,SB_115,SB_116,SB_131,SB_145,SB_165,SB_166,SB_170,SB_171,SB_172,SB_173,SB_187,SB_192,SB_195,SB_30,SB_36,SB_39,SB_6,SB_61,SB_68,SB_7,SB_84,SB_88,SB_9
Methods: 13C NMR, 1H NMR, GLC-MS, NMR-2D, HF solvolysis, sugar analysis, 31P NMR, ESI-MS, mild acid hydrolysis, ESI-MS/MS, NMR-1D, genetic methods, HPLC, alkaline hydrolysis, CE-ESI-MS
Biosynthesis and genetic data: genetic data; studies on wild type R2846 and its losB2 and lpsA mutants
Comments, role: The position of glycine could not be determined.
Related record ID(s): 22690, 23118, 23119, 23120, 23122, 23123, 31135, 31136
NCBI Taxonomy refs (TaxIDs): 262727
Show glycosyltransferases
There are 54 chemically distinct structures. Please, select:
xXCho?(1-P-6)[Ac(1-2)]bDGalp(1-2)[Ac(1-3),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-2),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-2),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-2)]bDGalp(1-2)[Ac(1-3),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-6),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-2),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-2)]bDGalp(1-2)[Ac(1-3),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-7),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-2),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-3)]bDGalp(1-2)[Ac(1-3),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-2),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-2),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-3)]bDGalp(1-2)[Ac(1-3),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-6),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-2),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-3)]bDGalp(1-2)[Ac(1-3),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-7),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-2),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-4)]bDGalp(1-2)[Ac(1-3),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-2),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-2),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-4)]bDGalp(1-2)[Ac(1-3),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-6),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-2),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-4)]bDGalp(1-2)[Ac(1-3),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-7),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-2),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-2)]bDGalp(1-2)[Ac(1-4),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-2),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-2),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-2)]bDGalp(1-2)[Ac(1-4),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-6),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-2),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-2)]bDGalp(1-2)[Ac(1-4),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-7),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-2),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-3)]bDGalp(1-2)[Ac(1-4),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-2),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-2),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-3)]bDGalp(1-2)[Ac(1-4),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-6),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-2),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-3)]bDGalp(1-2)[Ac(1-4),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-7),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-2),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-4)]bDGalp(1-2)[Ac(1-4),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-2),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-2),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-4)]bDGalp(1-2)[Ac(1-4),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-6),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-2),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-4)]bDGalp(1-2)[Ac(1-4),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-7),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-2),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-2)]bDGalp(1-2)[Ac(1-6),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-2),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-2),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-2)]bDGalp(1-2)[Ac(1-6),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-6),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-2),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-2)]bDGalp(1-2)[Ac(1-6),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-7),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-2),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-3)]bDGalp(1-2)[Ac(1-6),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-2),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-2),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-3)]bDGalp(1-2)[Ac(1-6),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-6),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-2),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-3)]bDGalp(1-2)[Ac(1-6),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-7),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-2),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-4)]bDGalp(1-2)[Ac(1-6),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-2),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-2),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-4)]bDGalp(1-2)[Ac(1-6),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-6),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-2),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-4)]bDGalp(1-2)[Ac(1-6),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-7),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-2),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-2)]bDGalp(1-2)[Ac(1-3),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-2),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-3),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-2)]bDGalp(1-2)[Ac(1-3),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-6),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-3),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-2)]bDGalp(1-2)[Ac(1-3),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-7),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-3),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-3)]bDGalp(1-2)[Ac(1-3),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-2),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-3),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-3)]bDGalp(1-2)[Ac(1-3),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-6),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-3),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-3)]bDGalp(1-2)[Ac(1-3),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-7),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-3),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-4)]bDGalp(1-2)[Ac(1-3),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-2),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-3),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-4)]bDGalp(1-2)[Ac(1-3),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-6),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-3),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-4)]bDGalp(1-2)[Ac(1-3),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-7),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-3),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-2)]bDGalp(1-2)[Ac(1-4),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-2),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-3),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-2)]bDGalp(1-2)[Ac(1-4),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-6),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-3),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-2)]bDGalp(1-2)[Ac(1-4),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-7),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-3),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-3)]bDGalp(1-2)[Ac(1-4),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-2),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-3),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-3)]bDGalp(1-2)[Ac(1-4),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-6),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-3),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-3)]bDGalp(1-2)[Ac(1-4),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-7),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-3),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-4)]bDGalp(1-2)[Ac(1-4),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-2),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-3),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-4)]bDGalp(1-2)[Ac(1-4),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-6),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-3),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-4)]bDGalp(1-2)[Ac(1-4),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-7),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-3),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-2)]bDGalp(1-2)[Ac(1-6),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-2),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-3),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-2)]bDGalp(1-2)[Ac(1-6),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-6),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-3),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-2)]bDGalp(1-2)[Ac(1-6),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-7),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-3),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-3)]bDGalp(1-2)[Ac(1-6),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-2),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-3),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-3)]bDGalp(1-2)[Ac(1-6),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-6),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-3),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-3)]bDGalp(1-2)[Ac(1-6),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-7),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-3),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-4)]bDGalp(1-2)[Ac(1-6),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-2),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-3),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-4)]bDGalp(1-2)[Ac(1-6),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-6),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-3),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
xXCho?(1-P-6)[Ac(1-4)]bDGalp(1-2)[Ac(1-6),P-7)]aXLDmanHepp(1-2)[xXEt?N(1-P-6)]aXLDmanHepp(1-3)[Ac(1-7),Ac(1-5)aXNeup(2-3)bDGalp(1-4)[Ac(1-2)]bDGlcpN(1-3)bDGalp(1-4)[Ac(1-3),bDGlcp(1-4)[%xXCho?(1-P-6)]aXDDmanHepp(1-6)]bDGlcp(1-4)]aXLDmanHepp(1-5)[xXEt?N(1-P-P-4)]aXKdop
report error
Found 1 record.
Displayed record 1
, Life stage: adult]; infection due to Haemophilus influenzae [ICD11: XN1P6 
ki.se