Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: infection due to Shigella dysenteriae [ICD11:
XN285 
];
infection due to Escherichia coli [ICD11:
XN6P4 ]
NCBI PubMed ID: 18695724Publication DOI: 10.1134/S1068162008040109Journal NLM ID: 9420101Publisher: Springer Science and Business Media
Correspondence: perepel
ioc.ac.ru
Institutions: Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia,TEDA School of Biological Sciences and Biotechnology, Nankai University, TEDA, China
The earlier established structures of the acidic O-specific polysaccharides from two typical strains of the Shigella dysenteriae bacterium were revised using modern NMR spectroscopy techniques. In particular, the configurations of the glycosidic linkages of GlcNAc (S. dysenteriae type 4) and mannose (S. dysenteriae type 5) residues were corrected. In addition, the location of the sites of non-stoichiometric O-acetylation in S. dysenteriae type 4 was determined: the lateral fucose residue was shown to be occasionally O-acetylated; also, theposition of the O-acetyl group present at the stoichiometric quantity in S. dysenteriae type 5 was corrected. The revised structures of the polysaccharides studied are shown below. The known identity of theO-specific polysaccharide structures of S. dysenteriae type 5 and Escherichia coli O58 was confirmed by 13C NMR spectroscopy and, hence, the structure of the E. coli O58 polysaccharide should be revised in the same manner.
structure, O-antigen, NMR spectroscopy, O-specific polysaccharide, O-Specific polysaccharide structure, Shigella dysenteriae
Structure type: suggested polymer biological repeating unit
Location inside paper: p.466
Compound class: O-polysaccharide
Contained glycoepitopes: IEDB_130701,IEDB_135813,IEDB_136105,IEDB_137340,IEDB_141807,IEDB_144983,IEDB_151531,IEDB_152206,IEDB_225177,IEDB_885823,IEDB_983930,SB_44,SB_67,SB_72
Methods: 13C NMR, 1H NMR, methylation, GLC-MS, NMR-2D, sugar analysis, GLC, mild acid hydrolysis, alkaline degradation, Smith degradation, NMR-1D
Comments, role: the structures ID 122453 and ID 122454 were revised in this work, but the revised structure contained another mistake introduced in this publication (GalN instead of GlcN).
Related record ID(s): 22716, 23210, 23211, 23213, 23214, 23215
NCBI Taxonomy refs (TaxIDs): 622,
562
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
report error