Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: infection due to Campylobacter jejuni [ICD11:
XN4Q5 
]
The structure was elucidated in this paperNCBI PubMed ID: 18346720Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: patricia.guerry
med.navy.mil; monteiro
uoguelph.ca
Institutions: Department of Chemistry, University of Guelph, Guelph, ON, Canada N1G 2W1
In line with our on-going efforts to create a multivalent anti-Campylobacter jejuni vaccine based on its capsule polysaccharides (CPSs), we report here the chemical structure and the genetic locus of the CPS produced by C. jejuni strain CG8486, which belongs to the serotype HS:4 CPS complex. C. jejuni CG8486 CPS was observed to be composed of approximately 17 disaccharide repeating blocks of 4-substituted N-acetyl-β-D-glucopyranosamine and 3-substituted 6-deoxy-β-D-ido-heptopyranose. A small number of 6-deoxy-β-D-ido-heptopyranose units were observed to carry O-methyl phosphoramidate moieties at the O-2 or O-7 position. The gene content and organization of the CPS locus of C. jejuni CG8486 were comparable to those of C. jejuni strains NCTC 11168 and 81-176, but several CG8486 CPS genes were observed to be more divergent from those present in the CPS loci of NCTC 11168 and 81-176 CPS, which indicated that there are genetic characteristics specific to the C. jejuni HS:4 CPS complex. The efficacy of a glycoconjugate vaccine based on C. jejuni CG8486 CPS is presently being tested in an animal model, the results of which will be presented in future communications
Campylobacter jejuni, capsule polysaccharide, Structural characterization, genetic locus, 6-deoxy-ido-heptopyranose
Structure type: polymer chemical repeating unit ; n=17
Location inside paper: p.1038
Trivial name: repeating unit of capsular polysaccharide
Compound class: CPS
Contained glycoepitopes: IEDB_135813,IEDB_137340,IEDB_141807,IEDB_151531
Methods: 13C NMR, 1H NMR, NMR-2D, GC-MS, sugar analysis, 31P NMR, GC, MALDI-TOF MS, genetic methods
Biosynthesis and genetic data: genetic data
NCBI Taxonomy refs (TaxIDs): 197
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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