Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Host organism: Homo sapiens
Associated disease: hemolytic-uremic syndrome (HUS) [ICD11:
3A21.2 
];
infection due to Escherichia coli [ICD11:
XN6P4 ]
NCBI PubMed ID: 12384293Journal NLM ID: 7706761Publisher: Amsterdam: Elsevier
Correspondence: reeves
angis.org.au
Institutions: Department Of Microbiology, School of Molecular and Microbial Biosciences (G08), University Of Sydney, Sydney, NSW 2006, Australia
Escherichia coli associated with outbreaks of gastroenteritis and hemolytic uremic syndrome include clones with O antigens O157 and O111. However, O26 has emerged as an O antigen present in pathogenic strains, particularly those implicated in cases of infantile gastroenteritis worldwide. The O26 O antigen gene cluster was sequenced. It was found to contain the genes expected for biosynthesis of nucleotide sugars L-rhamnose, N-acetyl-L-fucosamine and N-acetyl-glucosamine, as well genes for O unit flippase, O antigen polymerase and potential transferase genes. By polymerase chain reaction testing against representative strains for the 166 Escherichia coli O serogroups and some randomly selected Gram-negative bacteria, we identified three O antigen genes that are highly specific to O26. This work provides the basis for a sensitive test for the rapid detection of pathogenic clones with the O26 antigen, which has implications for public health, especially in the control of food-borne outbreaks
polymerase chain reaction, Molecular typing, transferases, Escherichia coli O26 gene cluster
Structure type: polymer chemical repeating unit
Location inside paper: p.126, fig.2
Compound class: O-polysaccharide, O-antigen
Contained glycoepitopes: IEDB_135813,IEDB_136105,IEDB_137340,IEDB_141807,IEDB_151531,IEDB_225177,IEDB_885823
Methods: PCR, genetic methods
Biological activity: serolical data
Biosynthesis and genetic data: genetic data
Related record ID(s): 3199, 10023, 20653
NCBI Taxonomy refs (TaxIDs): 404399Reference(s) to other database(s): GTC:G67201SZ, GlycomeDB:
25922
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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