Taxonomic group: bacteria / Spirochaetes
(Phylum: Spirochaetes)
Host organism: Homo sapiens
Associated disease: Lyme disease [ICD11:
1C1G 
, ICD11:
XN13C ]
NCBI PubMed ID: 17182019Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: pozsgayv
mail.nih.gov
Institutions: Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-2423, USA
A novel glycolipid was synthesized that corresponds to cholesteryl palmitoyl-galactopyranoside 1 found in the spirochete Borrelia burgdorferi, the causative agent of Lyme disease. In order to fashion 1 in a conjugatable form, the palmitoyl residue was modified to include a terminal aldehydo moiety that anchored the glycolipid to aminooxypropylated serum albumin using oxime chemistry. The glycolipoprotein so obtained incorporates an average of 18 glycolipid moieties per albumin molecule. The novel glycolipoprotein constructs are soluble in water and are candidates toward developing a semisynthetic vaccine against Lyme disease.
glycolipid, vaccine, Conjugation, Aminooxy, Borrelia burgdorferi, Glycolipoprotein, Lyme disease, Oxime
Structure type: monomer
Location inside paper: p.622, chart 1, 1
Aglycon: cholesteryl
Trivial name: cholesteryl palmitoyl-galactopyranoside
Compound class: glycolipid
Contained glycoepitopes: IEDB_136044,IEDB_137472,IEDB_141181,IEDB_141794,IEDB_190606,SB_165,SB_166,SB_187,SB_195,SB_7,SB_88
Methods: 13C NMR, 1H NMR, chemical methods
Synthetic data: chemical
NCBI Taxonomy refs (TaxIDs): 139
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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