Taxonomic group: bacteria / Firmicutes
(Phylum: Firmicutes)
Host organism: (mammal)
Associated disease: anthrax [ICD11:
1B97 
, ICD11:
XN94F ];
lung infections [ICD11:
CA4Y , ICD11:
CA4Z ];
infection due to Bacillus anthracis [ICD11:
XN94F ]
NCBI PubMed ID: 17205603Publication DOI: 10.1002/pmic.200600478Journal NLM ID: 101092707Publisher: Wiley-VCH
Correspondence: dwang1
stanford.edu
Institutions: Carbohydrate Microarray Laboratory, Stanford University School of Medicine, Stanford, CA, USA
Using photogenerated glycan arrays, we characterized a large panel of synthetic carbohydrates for their antigenic reactivities with pathogen-specific antibodies. We discovered that rabbit IgG antibodies elicited by Bacillus anthracis spores specifically recognize a tetrasaccharide chain that decorates the outermost surfaces of the B. anthracis exosporium. Since this sugar moiety is highly specific for the spores of B. anthracis, it appears to be a key biomarker for detection of B. anthracis spores and development of novel vaccines that target anthrax spores.
carbohydrates, antibody, bacteria, vaccines, Bacillus anthracis, Biomarker, Sugar chips
Structure type: oligomer
Location inside paper: p. 181 fig.1
Aglycon: 5-methoxycarbonylpentyl
Contained glycoepitopes: IEDB_133754,IEDB_136105,IEDB_146675,IEDB_146676,IEDB_150074,IEDB_225177,IEDB_885823
Methods: ELISA, serological methods
Biological activity: serological data
Comments, role: tetrasaccharide chain of the major glycoprotein of exosporium
NCBI Taxonomy refs (TaxIDs): 1392Reference(s) to other database(s): GlycomeDB:
37212
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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