Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Host organism: Homo sapiens
Associated disease: meningitis [ICD11:
1D01 
];
infection due to Neisseria meningitidis [ICD11:
XN1DV ]
NCBI PubMed ID: 19306991Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: rizor
units.it (R.Rizzo)
Institutions: Department of Life Sciences, University of Trieste, Bldg C11, Via Licio Giorgieri 1, 34127 Trieste, Italy
The effect of different cations on the conformational and morphological properties of the capsular polysaccharide produced by Neisseria meningitidis group A was investigated. Circular dichroism studies showed that the presence of Na(+), NH4+ or Ca(2+) ions induced different local conformations of the polysaccharide chain through interactions with the phosphodiester group bridging the saccharide residues in the polymer chain. Atomic force microscopy experiments confirmed that the morphology of the polysaccharide chains was different depending on the nature of the counterion. Ammonium ions were associated with the presence of single polymer chains in an elongated conformation, whereas sodium ions favored the folding of the chains into a globular conformation. The addition of calcium ions produced the aggregation of a limited number of globular polysaccharide chains to form a 'toroidal-like' structure
conformation, structure, Neisseria meningitidis, capsular polysaccharide, vaccines, atomic force microscopy
Structure type: homopolymer
Location inside paper: p.941, fig.1
Compound class: CPS
Contained glycoepitopes: IEDB_1330666,IEDB_1330667,IEDB_1330668,IEDB_1330669,IEDB_1330670,IEDB_1330671,IEDB_149549,IEDB_149550,IEDB_149551,IEDB_149552
Methods: light scattering, CD, atomic force microscopy
NCBI Taxonomy refs (TaxIDs): 65699Reference(s) to other database(s): GTC:G04962CQ, GlycomeDB:
34728
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
report error