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Cryptococcus neoformans D (Cap67)

(later renamed to: Cryptococcus neoformans var. neoformans (Cap67))
(NCBI TaxID 40410, species name lookup)

Taxonomic group: fungi / Basidiomycota (Phylum: Basidiomycota)
Associated disease: infection due to Cryptococcus neoformans [ICD11: XN3EH

]

NCBI PubMed ID: 19345342
Publication DOI: 10.1016/j.carres.2009.03.003
Journal NLM ID: 0043535
Publisher: Elsevier
Correspondence: Heiss C <cheiss

ccrc.uga.edu>, Heiss C <heiss8

bellsouth.net>
Institutions: Analytical Services/Complex Carbohydrate Research Center—University of Georgia, Athens, GA, USA, University of Iowa Carver College of Medicine and VA Medical Center, Iowa City, Iowa, USA, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA

The structure of galactoxylomannan, a capsular polysaccharide from the opportunistic yeast Cryptococcus neoformans, was re-examined by NMR spectroscopy and GC-MS. The residue that is 3-linked to the side chain galactose and was previously assigned as β-D-xylose [Vaishnav, V. V.; Bacon, B. E.; O'Neill, M.; Cherniak, R. Carbohydr. Res.1998, 306, 315-330] was determined to be β-D-glucuronic acid. A revised structure for this polymer is presented, along with a proposal that this compound be termed glucuronoxylomannogalactan (GXMGal).

structure, polysaccharides, glucuronic acid, CPS, Cryptococcus neoformans, GalXM

Structure type: polymer chemical repeating unit
Location inside paper: p.916, fig.1A (GalXM)
Trivial name: glucuronoxylomannogalactan (GXMGal)
Compound class: CPS
Contained glycoepitopes: IEDB_114701,IEDB_130701,IEDB_134624,IEDB_136044,IEDB_136906,IEDB_137472,IEDB_141794,IEDB_144983,IEDB_145668,IEDB_151528,IEDB_152206,IEDB_164174,IEDB_167188,IEDB_174332,IEDB_190606,IEDB_983930,SB_163,SB_165,SB_166,SB_187,SB_195,SB_197,SB_44,SB_67,SB_7,SB_72,SB_88

Methods: 13C NMR, 1H NMR, methylation, gel filtration, NMR-2D, GC-MS, sugar analysis, acid hydrolysis, GC, composition analysis, permethylation, reduction with NaBD4, acetylation
Comments, role: previously published structure obtained from C. neoformans D wild type

Related record ID(s): 24009, 45074
NCBI Taxonomy refs (TaxIDs): 40410
Reference(s) to other database(s): GTC:G16353MJ
Show glycosyltransferases

There is only one chemically distinct structure:

*OC[C@H]1O[C@H](OC[C@H]2O[C@H](*)[C@H](O)[C@@H](O)[C@H]2O)[C@H](O)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O[C@@H]5OC[C@@H](O)[C@H](O)[C@H]5O)[C@@H]4O)[C@@H]3O[C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)[C@H](O[C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)[C@H]2O)[C@H]1O

SVG MW SMILES 3D mol Ionize