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Taxonomic group: bacteria / Proteobacteria (Phylum: Proteobacteria)
Host organism: Homo sapiens
Associated disease: bronchitis [ICD11: CA20

, ICD11: CA20.Z

]; infection due to Pseudomonas aeruginosa [ICD11: XN5L6

]

NCBI PubMed ID: 19000720
Journal NLM ID: 8306883
Correspondence: Eleonora.altman

nrc-cnrc.gc.ca (E. Altman)
Institutions: Institute for Biological Sciences, National Research Council of Canada, 100 Sussex Drive, Ottawa, Ontario, Canada K1A 0R6

The aim of the present investigation was to develop a novel approach for rapid identification and differentiation of Pseudomonas aeruginosa clones from Canadian cystic fibrosis patients by capillary electrophoresis-mass spectrometry. We screened P. aeruginosa isolates for lipopolysaccharide structure and presence/absence of alginate and correlated these findings with antibiotic resistance patterns.

Lipopolysaccharide, structure, Pseudomonas aeruginosa, mass spectrometry, cystic fibrosis, drug resistance

Structure type: oligomer
Location inside paper: p.205, fig.2C
Aglycon: lipid A
Compound class: core oligosaccharide
Contained glycoepitopes: IEDB_130650,IEDB_130659,IEDB_1330403,IEDB_136105,IEDB_137473,IEDB_140088,IEDB_142488,IEDB_144144,IEDB_144998,IEDB_146664,IEDB_2189047,IEDB_225177,IEDB_885823,IEDB_983931,SB_192

Methods: serological methods, CE-MS
Biological activity: serological data
Comments, role: Pseudomonas aeruginosa strains belonging to clones B and unique nonA nonB

Related record ID(s): 23646, 23958
NCBI Taxonomy refs (TaxIDs): 287
Reference(s) to other database(s): GlycomeDB:37337
Show glycosyltransferases

There is only one chemically distinct structure:

CC(=O)OC[C@H]1O[C@H](O[C@@H]2[C@H](O)[C@@H](O[C@H]3[C@H](OP(=O)(O)O)[C@@H]([C@@H](O)CO)O[C@H](O[C@H]4[C@@H]([C@H](O)CO)O[C@@](O)(C(=O)O)C[C@H]4O[C@]4(C(=O)O)C[C@@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O4)[C@H]3OP(=O)(O)O)O[C@H]([C@H](CNC(=O)O)OP(=O)(O)O)[C@H]2O)[C@H](NC(=O)C(C)N)[C@@H](O[C@@H]2O[C@H](CO[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@@H](O)[C@H](O)[C@H]2O)[C@H]1O[C@H]1O[C@H](CO[C@@H]2O[C@@H](C)[C@H](O)[C@@H](O)[C@H]2O)[C@@H](O)[C@H](O)[C@H]1O

SVG MW SMILES 3D mol Ionize