Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: infection due to Escherichia coli [ICD11:
XN6P4 
]
NCBI PubMed ID: 36587069Publication DOI: 10.1007/978-1-0716-2910-9_4Journal NLM ID: 9214969Publisher: Springer
Correspondence: A. Shimoyama <ashimo
chem.sci.osaka-u.ac.jp>
Institutions: Graduate School of Science, Osaka University, Toyonaka, Osaka, Japan
Lipopolysaccharide (LPS), a cell surface component of Gram-negative bacteria, and its active principle, lipid A, have immunostimulatory properties and thus potential to act as adjuvants. However, canonical LPS acts as an endotoxin by hyperstimulating the immune response. Therefore, it is necessary to structurally modify LPS and lipid A to minimize toxicity while maintaining adjuvant effects for use as vaccine adjuvants. Various studies have focused on the chemical synthetic method of lipid As and their structure-activity relationship, which are reviewed in this chapter.
Lipopolysaccharide, lipid A, adjuvant, innate immunity, Alcaligenes faecalis, symbiotic bacteria
Structure type: oligomer
Location inside paper: Fig. 1
Trivial name: Kdo-lipid A
Compound class: lipid A
Contained glycoepitopes: IEDB_130650,IEDB_135394,IEDB_135515,IEDB_141807,IEDB_151531,IEDB_534864
Comments, role: review
NCBI Taxonomy refs (TaxIDs): 562
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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