Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: infection due to Brucella [ICD11:
XN22N 
]
NCBI PubMed ID: 21151694Journal NLM ID: 101516125Publisher: Hindawi Publishing Corporation
Correspondence: g.ferguson
abdn.ac.uk
Institutions: School of Medicine & Dentistry, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
Brucella species are the causative agents of one of the most prevalent zoonotic diseases: brucellosis. Infections by Brucella species cause major economic losses in agriculture, leading to abortions in infected animals and resulting in a severe, although rarely lethal, debilitating disease in humans. Brucella species persist as intracellular pathogens that manage to effectively evade recognition by the host's immune system. Sugar-modified components in the Brucella cell envelope play an important role in their host interaction. Brucella lipopolysaccharide (LPS), unlike Escherichia coli LPS, does not trigger the host's innate immune system. Brucella produces cyclic β-1,2-glucans, which are important for targeting them to their replicative niche in the endoplasmic reticulum within the host cell. This paper will focus on the role of LPS and cyclic β-1,2-glucans in Brucella-mammalian infections and discuss the use of mutants, within the biosynthesis pathway of these cell envelope structures, in vaccine development
biosynthesis, cell envelope, Brucella-mammalian infections
Structure type: cyclic polymer repeating unit ; n=17-24
Location inside paper: abstract, p.6
Trivial name: cyclosophoran, cyclic β-1,2-glucan, periplasmic cyclic β-1,2-glucan, cyclosophorans
Compound class: EPS
Contained glycoepitopes: IEDB_140628,IEDB_142488,IEDB_146664,IEDB_983931,SB_192
Comments, role: review
Related record ID(s): 7718, 116769, 139750
NCBI Taxonomy refs (TaxIDs): 234Reference(s) to other database(s): GTC:G21553SY, GlycomeDB:
25048
Show glycosyltransferases
There is only one chemically distinct structure:
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