Isshiki Y, Matsuura M, Dejsirilert S, Ezaki T, Kawahara K Separation of 6-deoxy-heptane from a smooth-type lipopolysaccharide preparation of Burkholderia pseudomallei FEMS Microbiology Reviews199 (2001)
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The structure was elucidated in this paper NCBI PubMed ID:11356562 Journal NLM ID:8902526 Publisher: Oxford University Press Correspondence: kawahara-kkitasato.or.jp Institutions: Department of Bacteriology, The Kitasato Institute, 5-9-1, Shirokane, Minato-ku, Tokyo 108-8642, Japan, Department of Microbiology, Jichi Medical School, 3311-1 Yakushiji, Minamikawachi-machi, Tochigi 329-0498, Japan, National Institute of Health, Nonthaburi 11000, Thailand, Department of Microbiology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu 500-8705, Japan
Smooth-type lipopolysaccharide (LPS) of Burkholderia pseudomallei has been reported to contain two kinds of O-antigenic polysaccharides, a 1,3-linked homopolymer of 6-deoxy-heptose and a polymer with a repeating unit of →3)-glucose-(1→3)-6-deoxytalose-(1→ with O-acetyl or O-methyl modifications. A LPS preparation containing these two polysaccharides was separated by gelpermeation chromatography in this study. Chemical analysis of the separated fractions revealed the 6-deoxy-heptane to be a polysaccharide without a lipid portion and the polymer of glucose and 6-deoxy-talose to be an O-antigenic polysaccharide of the LPS. This result was further supported by the assay of these polysaccharide molecules for macrophage activation activity. The 6-deoxy-heptane showed no macrophage activation, indicating that this polysaccharide was not the LPS, but one of the capsular polysaccharides of B. pseudomallei.
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(previously named: Pseudomonas pseudomallei)
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