Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: infection due to Burkholderia pseudomallei [ICD11:
XN3LD 
];
infection due to Pseudomonas pseudomallei [ICD11:
XN8AA ]
NCBI PubMed ID: 20837078Journal NLM ID: 8406899Publisher: Elsevier
Correspondence: J.L. Prior <JLPRIOR
dstl.gov.uk>
Institutions: Dstl Porton Down, Salisbury, Wiltshire SP4 0JQ, UK
Burkholderia thailandensis is a less virulent close relative of Burkholderia pseudomallei, a CDC category B biothreat agent. We have previously shown that lipopolysaccharide (LPS) extracted from B. pseudomallei can provide protection against a lethal challenge of B. pseudomallei in a mouse model of melioidosis. Sugar analysis on LPS from B. thailandensis strain E264 confirmed that this polysaccharide has a similar structure to LPS from B. pseudomallei. Mice were immunised with LPS from B. thailandensis or B. pseudomallei and challenged with a lethal dose of B. pseudomallei strain K96243. Similar protection levels were observed when either LPS was used as the immunogen. This data suggests that B. thailandensis LPS has the potential to be used as part of a subunit based vaccine against pathogenic B. pseudomallei
Lipopolysaccharide, Burkholderia pseudomallei, melioidosis, Burkholderia thailandensis
Structure type: polymer chemical repeating unit
Location inside paper: p.7552
Compound class: O-polysaccharide, O-antigen
Contained glycoepitopes: IEDB_142488,IEDB_146664,IEDB_983931,SB_192
Methods: GC-MS, SDS-PAGE, ELISA, acid hydrolysis, serological methods
Biological activity: serological data
NCBI Taxonomy refs (TaxIDs): 271848,
272560Reference(s) to other database(s): GTC:G94162FQ
Show glycosyltransferases
There is only one chemically distinct structure:
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