Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: infection due to Escherichia coli [ICD11:
XN6P4 
]
NCBI PubMed ID: 20349183Publication DOI: 10.1007/s00253-010-2531-5Journal NLM ID: 8406612Publisher: Springer
Correspondence: ma.ferrero
unileon.es; leandro.rodrigues
unileon.es
Institutions: Departamento de Biologia Molecular, Universidad de Leon, Campus de Vegazana, 24071, Leon, Spain
Polysialic acids (PA) are protective capsular sialohomopolymers present in some bacteria which can invade the mammalian host and cause lethal bacteremia and meningitis. Biosynthesis and translocation of PA to the cell surface are equivalent in different species and bacterial strains which are produced. The diversity in PA structure is derived from the PA linkages and is a consequence of the specific sialyltransferase activities. The monomer acetylation and the polymer length could be important factors in the potential virulence. In vivo PA production is affected by different physical and chemical factors. The temperature of cellular growth strictly regulates PA genesis through a molecular complex and multifactorial mechanism that operate to transcription level.
Neisseria meningitidis, Escherichia coli, N-acetylneuraminic acid, polysialic acids
Structure type: polymer chemical repeating unit
Location inside paper: fig.1c , table 1
Trivial name: colominic acid, polysialic acid, α-2,8/2,9-linked polysialic acid
Compound class: CPS, K-antigen
Contained glycoepitopes: IEDB_136794,IEDB_146100,IEDB_149174,IEDB_150937,IEDB_153199,SB_170,SB_171,SB_172,SB_35,SB_42,SB_84
Biological activity: metabolism of polysialic acid
Biosynthesis and genetic data: biosynthesis data
Comments, role: published polymerization frame was shifted for conformity with other records.
Related record ID(s): 5036, 6658, 25246, 25600
NCBI Taxonomy refs (TaxIDs): 562Reference(s) to other database(s): GTC:G85948DP, GlycomeDB:
26537
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
report error