Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Host organism: Homo sapiens
Associated disease: enterocolitis [ICD11:
1A40.Z 
];
septicemia [ICD11:
MA15.Y ];
meningitis [ICD11:
1D01 ]
The structure was elucidated in this paperNCBI PubMed ID: 20684949Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: M.B. Perry <malcolm.perry
nrc-cnrc.gc.ca>
Institutions: Institute for Biological Sciences, National Research Council, Ottawa, Canada
Strains of Cronobacter sakazakii (previously known as Enterobactersakazakii) are medically recognized important Gram-negative bacterial pathogens that cause enterocolitis, septicemia, and meningitis, with a high mortality rate in neonates. The structure of their O-antigens, that form part of their somatic lipopolysaccharide (LPS) components, is of interest for their chemical and serological identification and their relationship to virulence. The O-polysaccharide (O-PS) of C.sakazakii HPB 2855 (SK 81), a strain isolated from an infant at the Hospital for Sick Children in Toronto in 1981, was shown to be a polymer of a partially O-acetylated-repeating hexasaccharide unit composed of d-glucose, d-galacturonic acid, 2-acetamido-2-deoxy-d-galactose, and l-rhamnose (1:1:1:3). From composition and methylation analysis, and the application of 1D and 2D (1)H and (13)C NMR spectroscopy, the O-PS was determined to be a polymer of a repeating oligosaccharide unit having the structure: (formula, see text).
Lipopolysaccharide, polysaccharide, O-antigen, NMR spectroscopy, Cronobacter sakazakii
Structure type: polymer chemical repeating unit
Location inside paper: abstract
Compound class: O-polysaccharide
Contained glycoepitopes: IEDB_130422,IEDB_135813,IEDB_135849,IEDB_136105,IEDB_137340,IEDB_141807,IEDB_142488,IEDB_144998,IEDB_146664,IEDB_151531,IEDB_225177,IEDB_885823,IEDB_983931,SB_192
Methods: 13C NMR, 1H NMR, methylation, GLC-MS, sugar analysis, GLC, mild acid hydrolysis, DOC-PAGE, de-O-acetylation, NMR-1D, CE-MS
Comments, role: total O-Ac for side chain Rhap residue = 60%; published polymerization frame was shifted for conformity with other records
Related record ID(s): 25337, 25756
NCBI Taxonomy refs (TaxIDs): 28141Reference(s) to other database(s): GTC:G33736BO
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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(previously named: Enterobacter sakazakii HPB 2855)