Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Host organism: Homo sapiens
Associated disease: diarrhea [ICD11:
ME05.1 
, ICD11:
SA55 ];
hemorrhagic colitis (HC) [ICD11:
1A40.0 ];
hemolytic-uremic syndrome (HUS) [ICD11:
3A21.2 ];
infection due to Escherichia coli [ICD11:
XN6P4 ]
NCBI PubMed ID: 21928148Journal NLM ID: 8603310Publisher: Kluwer Academic Publishers
Correspondence: akmisra69
gmail.com
Institutions: Molecular Medicine Division, Bose Institute, P-1/12, C.I.T. Scheme VII M, Kolkata, 700054, India.
A convergent synthesis of the tetrasaccharide repeating unit of the O-antigen of the verotoxin producing E. coli O176 has been achieved in excellent yield adopting a [2 + 2] block glycosylation strategy. The β-D-mannosidic moiety of the tetrasaccharide was prepared from β-D-glucoside and α-D-galactosamine moiety was derived from D-galactal. The tetrasaccharide was synthesized as its 2-trimethylsilylethyl glycoside in excellent yield. All intermediate steps are high yielding.
oligosaccharide, O-antigen, diarrhea, glycosylation, E.coli
Structure type: suggested polymer biological repeating unit
Location inside paper: p.520, fig.1
Compound class: O-polysaccharide, O-antigen
Contained glycoepitopes: IEDB_130648,IEDB_130701,IEDB_136104,IEDB_137473,IEDB_137485,IEDB_1391961,IEDB_140116,IEDB_141584,IEDB_141830,IEDB_143632,IEDB_144983,IEDB_152206,IEDB_885822,IEDB_983930,SB_136,SB_196,SB_44,SB_67,SB_72
Methods: 13C NMR, 1H NMR, NMR-2D, TLC, chemical synthesis, glycosylation
Synthetic data: chemical
Comments, role: chemical repeat frame is different in the paper
Related record ID(s): 22712, 26634
NCBI Taxonomy refs (TaxIDs): 562Reference(s) to other database(s): GTC:G82509QD, GlycomeDB:
3519
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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