Taxonomic group: bacteria / Chlamydiae
(Phylum: Chlamydiae)
Host organism: Homo sapiens
Associated disease: trachoma [ICD11:
1C23 
, ICD11:
XN4Q4 ];
salpingitis [ICD11:
GA07 ];
pelvic inflammatory disease [ICD11:
GA05 , Sex: female];
infection due to Chlamydia trachomatis [ICD11:
XN4Q4 ]
NCBI PubMed ID: 21628561Journal NLM ID: 7505876Publisher: National Academy of Sciences
Correspondence: raetz
biochem.duke.edu
Institutions: Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.
Lipopolysaccharides (LPS) and lipooligosaccharides (LOS) are the main lipid components of bacterial outer membranes and are essential for cell viability in most Gram-negative bacteria. Here we show that small molecule inhibitors of LpxC [UDP-3-O-(R-3-hydroxymyristoyl)-GlcNAc deacetylase], the enzyme that catalyzes the first committed step in the biosynthesis of lipid A, block the synthesis of LOS in the obligate intracellular bacterial pathogen Chlamydia trachomatis. In the absence of LOS, Chlamydia remains viable and establishes a pathogenic vacuole ('inclusion') that supports robust bacterial replication. However, bacteria grown under these conditions were no longer infectious. In the presence of LpxC inhibitors, replicative reticulate bodies accumulated in enlarged inclusions but failed to express selected late-stage proteins and transition to elementary bodies, a Chlamydia developmental form that is required for invasion of mammalian cells. These findings suggest the presence of an outer membrane quality control system that regulates Chlamydia developmental transition to infectious elementary bodies and highlights the potential application of LpxC inhibitors as unique class of antichlamydial agents.
Lipooligosaccharide, lipid A, Chlamydia trachomatis, outer membrane
Structure type: oligomer
Location inside paper: p.10285, fig.1
Trivial name: genus-specific epitope
Compound class: core oligosaccharide
Contained glycoepitopes: IEDB_130650,IEDB_130657,IEDB_130658,IEDB_130659,IEDB_135394,IEDB_135515,IEDB_141807,IEDB_150760,IEDB_150908,IEDB_151531,IEDB_176772,IEDB_534865
Methods: genetic methods
Biosynthesis and genetic data: genetic data,biochemical data
NCBI Taxonomy refs (TaxIDs): 813
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
report error