Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Host organism: Homo sapiens
Associated disease: typhoid fever [ICD11:
1A07 
, ICD11:
XN4AM ];
infection due to Salmonella typhi [ICD11:
XN4AM ]
NCBI PubMed ID: 21098104Publication DOI: 10.1128/IAI.00961-10Journal NLM ID: 0246127Publisher: American Society for Microbiology
Correspondence: ajbaumler
ucdavis.edu
Institutions: Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Ave., Davis, CA 95616-8645, USA.
Capsular polysaccharides are important virulence factors of invasive bacterial pathogens. Here we studied the role of the virulence (Vi) capsular polysaccharide of Salmonella enterica serotype Typhi (S. Typhi) in preventing innate immune recognition by complement. Comparison of capsulated S. Typhi with a noncapsulated mutant (∆tviBCDE vexABCDE mutant) revealed that the Vi capsule interfered with complement component 3 (C3) deposition. Decreased complement fixation resulted in reduced bacterial binding to complement receptor 3 (CR3) on the surface of murine macrophages in vitro and decreased CR3-dependent clearance of Vi capsulated S. Typhi from the livers and spleens of mice. Opsonization of bacteria with immune serum prior to intraperitoneal infection increased clearance of capsulated S. Typhi from the liver. Our data suggest that the Vi capsule prevents CR3-dependent clearance, which can be overcome in part by a specific antibody response.
virulence, Salmonella enterica, Salmonella typhi, Vi capsular polysaccharide
Structure type: polymer chemical repeating unit
Location inside paper: p.836, fig.6A
Compound class: O-antigen
Contained glycoepitopes: IEDB_130701,IEDB_136105,IEDB_136906,IEDB_137472,IEDB_139421,IEDB_141794,IEDB_144983,IEDB_151528,IEDB_152206,IEDB_190606,IEDB_225177,IEDB_885823,IEDB_983930,SB_44,SB_67,SB_7,SB_72
Methods: PCR, DNA cloning, serological methods, statistical analysis
Biological activity: serological data
Biosynthesis and genetic data: genetic data
Related record ID(s): 27011
NCBI Taxonomy refs (TaxIDs): 90370Reference(s) to other database(s): GTC:G31611QH
Show glycosyltransferases
There is only one chemically distinct structure:
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(later renamed to: Salmonella enterica ssp. enterica sv. Typhi)