Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: chronic gastritis [ICD11:
DA42.Z 
, ICD11:
XT8W ];
peptic ulcer [ICD11:
DA61 , ICD11:
XN3DY ];
gastric cancer [ICD11:
2B72.Z ];
infection due to Helicobacter pylori [ICD11:
XN3DY ]
The structure was elucidated in this paperNCBI PubMed ID: 21903201Publication DOI: 10.1016/j.carres.2011.06.036Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: evguenii.vinogradov
nrc-cnrc.gc.ca; evguenii.vinogradov
nrc.ca
Institutions: Institute for Biological Sciences, National Research Council Canada, Ottawa, Canada
We describe a re-investigation of the structure of the lipopolysaccharide (LPS) from Helicobacter pylori genomic strain 26695 and its corresponding HP0826::Kan mutant lacking the O-chain component based on the in-depth NMR analysis of the oligosaccharide products obtained through the use of various degradation procedures performed on the purified LPS from both strains, as well as CE-MS data. New structural evidence indicates the presence of the linear arrangement of glucan and heptan portions of the LPS attached through -6-α-ddHep-3-α-L-Fuc-3-β-GlcNAc- fragment to the inner core dd-heptose residue. This structure differs from previously reported structures of the H. pylori 26695 LPS in several aspects
Lipopolysaccharide, NMR, LPS, structure, Helicobacter pylori
Structure type: oligomer
Location inside paper: p.2439, fig.1
Compound class: LPS
Contained glycoepitopes: IEDB_120354,IEDB_123890,IEDB_130650,IEDB_135813,IEDB_136044,IEDB_136045,IEDB_137340,IEDB_137472,IEDB_140088,IEDB_141794,IEDB_141807,IEDB_142488,IEDB_142489,IEDB_144562,IEDB_144998,IEDB_145669,IEDB_146664,IEDB_150092,IEDB_151531,IEDB_152214,IEDB_174333,IEDB_190606,IEDB_2189046,IEDB_2189047,IEDB_983931,SB_165,SB_166,SB_187,SB_192,SB_195,SB_7,SB_86,SB_88
Methods: 13C NMR, 1H NMR, methylation, periodate oxidation, GLC-MS, NMR-2D, sugar analysis, 31P NMR, deacylation, deamination, de-O-acylation with hydrazine, NMR-1D, CE-MS
Comments, role: lipid A part (two GlcpN residues in the main chain) is acylated
Related record ID(s): 26129, 26558, 26560, 26561, 26562, 26563, 26564, 26565, 26566, 26567, 26568, 26569, 26570
NCBI Taxonomy refs (TaxIDs): 85962
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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