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Taxonomic group: bacteria / Proteobacteria (Phylum: Proteobacteria)
Host organism: Sus scrofa
Associated disease: septicemia [ICD11: MA15.Y

]; pleuropneumonia [ICD11: CA40

, ICD11: CA40.Y

]; meningitis [ICD11: 1D01

]; gastroenteritis [ICD11: 1A40.0

]; enterocolitis [ICD11: 1A40.Z

]

NCBI PubMed ID: 21639829
Publication DOI: 10.1139/o11-003
Journal NLM ID: 8606068
Publisher: Ottawa: National Research Council of Canada
Correspondence: M.A. Monteiro <monteiro

uoguelph.ca>
Institutions: Department of Chemistry, University of Guelph, Canada

The Gram-negative bacteria Actinobacillus suis colonizes the upper respiratory and genital tracts of swine. Along with capsular polysaccharides, lipopolysaccharides (O-chain→core→lipid A~cell) are a main cell-surface component of A. suis. In this study, we determined that A. suis lipopolysaccharide incorporates a conserved core that shares some structural features with several core types of A. pleuropneumoniae . These common core structural features likely account for the observed serological cross-reactivity between A. suis and A. pleuropneumoniae, and the data suggest that the structural epitopes responsible for immunogenicity are those in the outer core domain.

Lipopolysaccharide, core, Actinobacillus suis, Actinobacillus pleuropneumoniae

Structure type: oligomer
Location inside paper: p.357, fig.7(b)
Compound class: core oligosaccharide
Contained glycoepitopes: IEDB_130650,IEDB_137779,IEDB_138949,IEDB_139428,IEDB_140087,IEDB_140088,IEDB_140090,IEDB_142488,IEDB_144998,IEDB_146664,IEDB_2189046,IEDB_2189047,IEDB_983931,SB_192

Methods: 13C NMR, 1H NMR, NMR-2D, sugar analysis, ESI-MS, MS/MS, NMR-1D, immunoblotting
3D data: molecular modeling

Related record ID(s): 26206, 26288, 26630, 26631
NCBI Taxonomy refs (TaxIDs): 715
Reference(s) to other database(s): GTC:G63363FS
Show glycosyltransferases

There are 2 chemically distinct structures. Please, select:

O=C(O)C1(O)C[C@@H](O)[C@@H](O[C@H]2O[C@H]([C@H](CO)O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@@H](O[C@@H]3O[C@H](CO[C@H]4O[C@H]([C@@H](CO)O[C@H]5O[C@H]([C@H](O)CO)[C@@H](O)[C@H](O)[C@@H]5O)[C@@H](O)[C@H](O)[C@@H]4O)[C@@H](O)[C@H](O)[C@H]3O)[C@H](O[C@H]3O[C@H]([C@@H](O)CO)[C@@H](O)[C@H](O)[C@@H]3O[C@H]3O[C@H]([C@@H](O)CO)[C@@H](O)[C@H](O)[C@@H]3O)[C@@H]2O)[C@@H]([C@H](O)CO)O1

SVG MW SMILES 3D mol Ionize