Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: infection due to Escherichia coli [ICD11:
XN6P4 
]
NCBI PubMed ID: 21999538Publication DOI: 10.1134/S0006297911070078Journal NLM ID: 0376536Publisher: Nauka/Interperiodica
Correspondence: perepel
ioc.ac.ru
Institutions: N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow
The O-polysaccharide (O-antigen) of Salmonella enterica O51 was isolated by mild acid degradation of the lipopolysaccharide and its structure was established using sugar analysis and NMR spectroscopy. The O-antigen of Escherichia coli O23, whose structure was elucidated earlier, possesses a similar structure and differs only in the presence of an additional lateral ?-D-Glcp residue at position 6 of the GlcNAc residue in the main chain. Sequencing of the O-antigen gene clusters of S. enterica O51 and E. coli O23 revealed the same genes with a high-level similarity. By comparison with opened gene databases, all genes expected for the synthesis of the common structure of the two O-antigens were assigned functions. It is suggested that the gene clusters of both bacteria originated from a common ancestor, whereas the O-antigen modification in E. coli O23, which, most probably, is induced by prophage genes outside the gene cluster, could be introduced after the species divergence.
Lipopolysaccharide, structure, O antigen, Escherichia coli, gene cluster, Bacterial polysaccharide, Salmonella enterica
Structure type: suggested polymer biological repeating unit
Location inside paper: p.777, fig.2, 2
Contained glycoepitopes: IEDB_130648,IEDB_134627,IEDB_135813,IEDB_136044,IEDB_137340,IEDB_137472,IEDB_137473,IEDB_1391961,IEDB_1391963,IEDB_141584,IEDB_141794,IEDB_141807,IEDB_142488,IEDB_143260,IEDB_144998,IEDB_146664,IEDB_151531,IEDB_190606,IEDB_885822,IEDB_983931,SB_165,SB_166,SB_173,SB_187,SB_192,SB_195,SB_23,SB_24,SB_7,SB_8,SB_88
Methods: 13C NMR, 1H NMR, NMR-2D, sugar analysis, DNA techniques, acid hydrolysis, GLC
Biosynthesis and genetic data: genetic data
Related record ID(s): 20006, 26306, 30377
NCBI Taxonomy refs (TaxIDs): 1095708Reference(s) to other database(s): GTC:G54329CO
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There is only one chemically distinct structure:
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