Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: infection due to Escherichia coli [ICD11:
XN6P4 
];
infection due to Shigella boydii [ICD11:
XN8RN ]
NCBI PubMed ID: 21347714Journal NLM ID: 8603310Publisher: Kluwer Academic Publishers
Correspondence: John.Raedts
wur.nl
Institutions: Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, The Netherlands
Glycosaminoglycans (GAGs) are polysaccharides that are typically present in a wide diversity of animal tissue. Most common GAGs are well-characterized and pharmaceutical applications exist for many of these compounds, e.g. heparin and hyaluronan. In addition, also bacterial glycosaminoglycan-like structures exist. Some of these bacterial GAGs have been characterized, but until now no bacterial GAG has been found that possesses the modifications that are characteristic for many of the animal GAGs such as sulfation and C5-epimerization. Nevertheless, the latter conversion may also occur in bacterial and archaeal GAGs, as some prokaryotic polysaccharides have been demonstrated to contain L-iduronic acid. However, experimental evidence for the enzymatic synthesis of L-iduronic acid in prokaryotes is as yet lacking. We therefore performed an in silico screen for D-glucuronyl C5-epimerases in prokaryotes. Multiple candidate C5-epimerases were found, suggesting that many more microorganisms are likely to exist possessing an L-iduronic acid residue as constituent of their cell wall polysaccharides.
Lipopolysaccharide, glycosaminoglycans, capsule polysaccharide, L-iduronic acid, D-glucuronyl C5-epimerase
Structure type: polymer chemical repeating unit
Location inside paper: p.60, fig.1
Compound class: O-antigen
Contained glycoepitopes: IEDB_130648,IEDB_135813,IEDB_136021,IEDB_137340,IEDB_137473,IEDB_1391961,IEDB_1391965,IEDB_141584,IEDB_141807,IEDB_142488,IEDB_144998,IEDB_146664,IEDB_151531,IEDB_423113,IEDB_885822,IEDB_983931,SB_192
Related record ID(s): 26323, 26943
NCBI Taxonomy refs (TaxIDs): 2184071,
621Reference(s) to other database(s): GTC:G34491JZ
Show glycosyltransferases
There is only one chemically distinct structure:
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