Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: infection due to Escherichia coli [ICD11:
XN6P4 
]
NCBI PubMed ID: 23059767Publication DOI: 10.1016/j.carres.2012.09.005Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: akmisra69
gmail.com (A.K. Misra)
Institutions: Bose Institute, Division of Molecular Medicine, P-1/12, C.I.T. Scheme VII-M, Kolkata 700054, India
A straightforward synthesis of the pentasaccharide with all α-linked glycosyl linkages corresponding to the cell wall O-antigen of Escherichia coli 19ab has been achieved in excellent yield using sequential glycosylations of monosaccharide intermediates. The structure of the target compound and its synthetic intermediates were unambiguously characterized using their spectral analysis. A generalized glycosylation condition has been used in all glycosylations and minimum number of protecting group manipulations were involved during the synthesis of the target compound.
oligosaccharide, O-antigen, Escherichia coli, pentasaccharide, glycosylation
Structure type: suggested polymer biological repeating unit
Location inside paper: p.9, fig.1
Compound class: O-polysaccharide, O-antigen
Contained glycoepitopes: IEDB_133754,IEDB_136105,IEDB_137340,IEDB_141807,IEDB_142488,IEDB_144825,IEDB_144998,IEDB_146664,IEDB_151531,IEDB_225177,IEDB_885823,IEDB_983931,SB_192
Methods: 13C NMR, 1H NMR, TLC, MALDI-MS, chemical methods, glycosylation
Synthetic data: chemical
Comments, role: Chemical repeat frame positioning is different in the paper.
Related record ID(s): 325, 26310, 28346, 30310
NCBI Taxonomy refs (TaxIDs): 1095707Reference(s) to other database(s): GTC:G27270SE
Show glycosyltransferases
There is only one chemically distinct structure:
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