Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: bacteremia [ICD11:
MA15.0 
];
neonatal necrotising enterocolitis [ICD11:
KB88 , Life stage: neonatal];
neonatal meningitis [ICD11:
KA65.4 , Life stage: neonatal]
NCBI PubMed ID: 22578769Publication DOI: 10.1016/j.carres.2012.02.031Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: yknirel
gmail.com
Institutions: ND Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia
The O-specific polysaccharide (O-antigen) was isolated from the lipopolysaccharide of Cronobacter sakazakii G2726 (serotype O3) and studied by sugar analysis, Smith degradation, and (1)H and (13)C NMR spectroscopy. The following structure of the acidic O-polysaccharide was established: [structure: see text]. This structure is closely related to that of the O-polysaccharide of Cronobacter muytjensii 3270, which has the same main chain and differs only in the lack of glucosylation. The O-antigen gene cluster of C. sakazakii G2726 found between the gnd and galF genes was sequenced, and the gene functions were tentatively assigned by similarity to related genes from available databases and taking into account the O-polysaccharide structure.
Lipopolysaccharide, O-specific polysaccharide, bacterial polysaccharide structure, O-antigen gene cluster, Cronobacter sakazakii
Structure type: polymer chemical repeating unit
Location inside paper: p.53, chart 1
Compound class: O-polysaccharide, O-antigen
Contained glycoepitopes: IEDB_115136,IEDB_130648,IEDB_136105,IEDB_137340,IEDB_137473,IEDB_1391961,IEDB_140630,IEDB_141584,IEDB_141807,IEDB_151531,IEDB_225177,IEDB_423153,IEDB_885822,IEDB_885823
Methods: 13C NMR, 1H NMR, NMR-2D, DNA sequencing, sugar analysis, acid hydrolysis, GLC, Smith degradation, NMR-1D, GPC
Comments, role: published polymerization frame was shifted for conformity with other records
Related record ID(s): 27109, 28858
NCBI Taxonomy refs (TaxIDs): 413501Reference(s) to other database(s): GTC:G25604QJ, GlycomeDB:
37289
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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