Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Host organism: Homo sapiens
Associated disease: cystic fibrosis (CF) [ICD11:
CA25 
]
The structure was elucidated in this paperNCBI PubMed ID: 22209378Publication DOI: 10.1016/j.carres.2011.12.007Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: ebedini
unina.it (E. Bedini)
Institutions: Dipartimento di Chimica Organica e Biochimica, Universita di Napoli 'Federico II', Complesso Universitario Monte S.Angelo, Via Cintia 4, 80126 Napoli, Italy
The synthesis of β-Gal-(1→3)-α-GalNAc-(1→3)-β-GalNAc allyl trisaccharide as the outer core fragment of Burkholderia cepacia pv. vietnamiensis lipooligosaccharide was accomplished through a concise, optimized, multi-step synthesis, having as key steps three glycosylations, that were in-depth studied performing them under several conditions. The target trisaccharide was designed with an allyl aglycone in order to open a future access to the conjugation with an immunogenic protein en route to the development of a synthetic neoglycoconjugate vaccine against this Burkholderia pathogen.
Burkholderia cepacia, trisaccharide, galactose, glycosylation, N-acetyl-galactosamine, orthoester
Structure type: oligomer
Location inside paper: p.27, scheme 2, 20
Trivial name: outer core fragment of LOS
Compound class: core oligosaccharide
Contained glycoepitopes: IEDB_130648,IEDB_134627,IEDB_136044,IEDB_137472,IEDB_137473,IEDB_1391961,IEDB_1391963,IEDB_141582,IEDB_141584,IEDB_141794,IEDB_143260,IEDB_153207,IEDB_190606,IEDB_885822,SB_165,SB_166,SB_187,SB_195,SB_23,SB_24,SB_7,SB_8,SB_88
Methods: 13C NMR, 1H NMR, TLC, MALDI-MS, glycosylation, conjugation, chemical synthesis methods
Synthetic data: chemical
Related record ID(s): 27117
NCBI Taxonomy refs (TaxIDs): 60552
Show glycosyltransferases
There is only one chemically distinct structure:
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(previously named: Pseudomonas cepacia pv. vietnamiensis)