Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: plague [ICD11:
1B93 
, ICD11:
XN6QS ];
infection due to Yersinia pestis [ICD11:
XN6QS ]
NCBI PubMed ID: 23150803Journal NLM ID: 101525823Publisher: Moscow: Park Media Ltd
Correspondence: knirel
ioc.ac.ru
Institutions: Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia
The present review summarizes data pertaining to the composition and structure of the carbohydrate moiety (core oligosaccharide) and lipid component (lipid A) of the various forms of lipopolysaccharide (LPS), one of the major pathogenicity factors ofYersinia pestis, the cause of plague. The review addresses the functions and the biological significance of genes for the biosynthesis of LPS, as well as the biological properties of LPS in strains from various intraspecies groups ofY. pestis and their mutants, including the contribution of LPS to the resistance of bacteria to factors of the innate immunity of both insect-vectors and mammal-hosts. Special attention is paid to temperature-dependent variations in the LPS structure, their genetic control and roles in the pathogenesis of plague. The evolutionary aspect is considered based on a comparison of the structure and genetics of the LPS ofY. pestis and other enteric bacteria, including otherYersinia species. The prospects of development of live plague vaccines created on the basis ofY. pestis strains with the genetically modified LPS are discussed.
Lipopolysaccharide, lipid A, immune response, Yersinia pestis, Plague, antibiotic resistance
Structure type: oligomer
Location inside paper: p.49, fig.2D
Compound class: lipid A
Contained glycoepitopes: IEDB_141807,IEDB_151531,IEDB_534864
Comments, role: Hexaacyl form synthesized by a recombinant strain of Y. pestis bearing the lpxL gene of E. coli at 37°C and 26°C.
Related record ID(s): 27212, 28419, 28420, 28421, 28422, 28423, 28425, 28426
NCBI Taxonomy refs (TaxIDs): 632
Show glycosyltransferases
There is only one chemically distinct structure:
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