Kubler-Kielb J, Vinogradov E The study of the core part and non-repeating elements of the O-antigen of Brucella lipopolysaccharide Carbohydrate Research366 (2013)
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The structure was elucidated in this paper NCBI PubMed ID:23261780 Publication DOI:10.1016/j.carres.2012.11.004 Journal NLM ID:0043535 Publisher: Elsevier Correspondence: E. Vinogradov <evguenii.vinogradovnrc.ca> Institutions: Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA, National Research Council, Ottawa, ON, Canada K1A 0RA6
Brucella is an animal and human pathogen that expresses several virulence factors required for host cell invasion and intracellular survival. It produces LPS with unusually low toxicity, which hampers the detection of bacteria by the host immune system and thus provides resistance against intracellular antimicrobial mechanisms of the host. By chemical and spectroscopic methods we determined the structure of the LPS core and of a non-repetitive oligosaccharide fragment at the reducing end of the O-specific polysaccharide. These data should be useful for understanding the biological role of the Brucella LPS.
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