Taxonomic group: protista / Euglenozoa
(Phylum: Euglenozoa)
Host organism: (mammal)
Organ / tissue: cell surface,
Life stage: trypomastigoteAssociated disease: Chagas disease [ICD11:
1F53 
, ICD11:
XN56V ];
infection due to Trypanosoma cruzi [ICD11:
XN56V ]
NCBI PubMed ID: 23230438Publication DOI: 10.3389/fimmu.2012.00356Journal NLM ID: 101560960Publisher: Lausanne: Frontiers Research Foundation
Correspondence: adrianet
biof.ufrj.br
Institutions: Laboratório de Glicobiologia Estrutural e Funcional, Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro Brazil
Commonly found at the outermost ends of complex carbohydrates in extracellular medium or on outer cell membranes, sialic acids play important roles in a myriad of biological processes. Mammals synthesize sialic acid through a complex pathway, but Trypanosoma cruzi, the agent of Chagas' disease, evolved to obtain sialic acid from its host through a trans-sialidase (TcTS) reaction. Studies of the parasite cell surface architecture and biochemistry indicate that a unique system comprising sialoglycoproteins and sialyl-binding proteins assists the parasite in several functions including parasite survival, infectivity, and host-cell recognition. Additionally, TcTS activity is capable of extensively remodeling host cell glycomolecules, playing a role as virulence factor. This review presents the state of the art of parasite sialobiology, highlighting how the interplay between host and parasite sialic acid helps the pathogen to evade host defense mechanisms and ensure lifetime host parasitism.
sialic acid, immune response, sialidase, glycoconjugate, Trypanosoma cruzi, Parasite
Structure type: fragment of a bigger structure
Location inside paper: p. 356-2, Fig. 3(C)
Trivial name: mucin-like glycoprotein
Compound class: glycoprotein
Contained glycoepitopes: IEDB_135813,IEDB_136044,IEDB_136095,IEDB_136794,IEDB_137340,IEDB_137472,IEDB_141794,IEDB_141807,IEDB_146100,IEDB_149174,IEDB_150933,IEDB_151531,IEDB_190606,SB_116,SB_165,SB_166,SB_170,SB_171,SB_172,SB_187,SB_195,SB_39,SB_68,SB_7,SB_84,SB_88
Enzymes that release or process the structure: trans-sialidase (TcTS)
Comments, role: review
NCBI Taxonomy refs (TaxIDs): 5693
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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