Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: meningitis [ICD11:
1D01 
];
infection due to Escherichia coli [ICD11:
XN6P4 ]
Publication DOI: 10.3762/bjoc.9.203Journal NLM ID: 101250746Publisher: Beilstein-Institut
Correspondence: akmisra69
gmail.com
Institutions: Bose Institute, Division of Molecular Medicine, P-1/12, C.I.T. Scheme VII-M, Kolkata-700054, India
A straightforward synthesis of the tetrasaccharide repeating unit of the O-antigen of Escherichia coli O16 has been achieved following a sequential glycosylation strategy. A minimum number of steps was used for the synthesis of the target compound involving a one-pot glycosylation and a protecting group manipulation. All intermediate reactions afford their products in high yield, and the glycosylation steps are stereoselective.
Lipopolysaccharide, tetrasaccharide, O-antigen, Escherichia coli, glycosylation
Structure type: polymer chemical repeating unit
Location inside paper: p.1758
Compound class: O-polysaccharide, O-antigen
Contained glycoepitopes: IEDB_136095,IEDB_136105,IEDB_137340,IEDB_137472,IEDB_141807,IEDB_142488,IEDB_144998,IEDB_146664,IEDB_151531,IEDB_158539,IEDB_190606,IEDB_225177,IEDB_885823,IEDB_983931,SB_192
Methods: 13C NMR, 1H NMR, NMR-2D, TLC, chemical synthesis, NMR-1D, glycosylation
Synthetic data: chemical
Related record ID(s): 29587
NCBI Taxonomy refs (TaxIDs): 1010799Reference(s) to other database(s): GTC:G11448UK
Show glycosyltransferases
There is only one chemically distinct structure:
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