Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: infection due to Brucella melitensis [ICD11:
XN7ZW 
]
NCBI PubMed ID: 23166489Publication DOI: 10.1371/journal.ppat.1002983Journal NLM ID: 101238921Publisher: San Francisco, CA: Public Library of Science
Correspondence: gorvel
ciml.univ-mrs.fr
Institutions: Centre d'Immunologie de Marseille-Luminy, Aix-Marseille University, UM2, Marseille, France
Bacterial cyclic glucans are glucose polymers that concentrate within the periplasm of alphaproteobacteria. These molecules are necessary to maintain the homeostasis of the cell envelope by contributing to the osmolarity of Gram negative bacteria. Here, we demonstrate that Brucella β 1,2 cyclic glucans are potent activators of human and mouse dendritic cells. Dendritic cells activation by Brucella β 1,2 cyclic glucans requires TLR4, MyD88 and TRIF, but not CD14. The Brucella cyclic glucans showed neither toxicity nor immunogenicity compared to LPS and triggered antigen-specific CD8(+) T cell responses in vivo. These cyclic glucans also enhanced antigen-specific CD4(+) and CD8(+) T cell responses including cross-presentation by different human DC subsets. Brucella β 1,2 cyclic glucans increased the memory CD4(+) T cell responses of blood mononuclear cells exposed to recombinant fusion proteins composed of anti-CD40 antibody and antigens from both hepatitis C virus and Mycobacterium tuberculosis. Thus cyclic glucans represent a new class of adjuvants, which might contribute to the development of effective antimicrobial therapies
Brucella, β-1, dendritic cells, 2 cyclic glucans
Structure type: cyclic polymer repeating unit ; n=17-25
Location inside paper: p.e1002983, 1
Trivial name: cyclosophoran, cyclic β-1,2-glucan, cyclic b-glucan
Compound class: EPS, glucan, cyclic b-glucan
Contained glycoepitopes: IEDB_140628,IEDB_142488,IEDB_146664,IEDB_983931,SB_192
Methods: MALDI-TOF MS, biological assays, serological methods, genetic methods
Biological activity: toxicity and immunogenicity of the cyclic glucan
NCBI Taxonomy refs (TaxIDs): 29459Reference(s) to other database(s): GTC:G21553SY, GlycomeDB:
25048
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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