Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Host organism: Homo sapiens
Associated disease: bacillary dysentery (shigellosis) [ICD11:
1A02 
, ICD11:
SA56 , ICD11:
XN7HG ];
infection due to Shigella flexneri [ICD11:
XN7Y2 ]
NCBI PubMed ID: 23603189Publication DOI: 10.1016/j.carres.2013.03.015Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: A.V. Perepelov <perepel
ioc.ac.ru>
Institutions: ND Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia
Recently, strains of a novel Shigella flexneri serotype called 1d have been isolated from diarrheal patients in China. They are distinguished by the presence of a hitherto unknown combination of type O-factor I and group O-factor 7,8, both associated with lateral ?-D-glucosyl groups on the basal linear O-polysaccharide. A serologically identical strain, 036_1d, has been constructed in the laboratory by sequential infection of serotype Y by serotype-converting bacteriophages SfX and SfI. In this work, using 1D and 2D (1)H and (13)C NMR spectroscopy, we established the following structure of the O-antigen of S. flexneri serotype 1d and demonstrated that the O-antigen of the 036_1d construct has the same structure: [structure: see text].
O-antigen, Shigella flexneri, serological classification, bacterial polysaccharide structure, Phage-encoded glucosylation
Structure type: polymer chemical repeating unit
Location inside paper: p.93
Compound class: O-polysaccharide, O-antigen, Shigella serogroup Y antigen, rhamnoglucan
Contained glycoepitopes: IEDB_125613,IEDB_125614,IEDB_127514,IEDB_133752,IEDB_133753,IEDB_133754,IEDB_135813,IEDB_135849,IEDB_136105,IEDB_137340,IEDB_141807,IEDB_141815,IEDB_141816,IEDB_143253,IEDB_151531,IEDB_153213,IEDB_225177,IEDB_885823
Methods: 13C NMR, 1H NMR, NMR-2D, mild acid hydrolysis, de-O-acetylation, NMR-1D, GPC
Related record ID(s): 29761
NCBI Taxonomy refs (TaxIDs): 424720Reference(s) to other database(s): GTC:G98477AV, GlycomeDB:
3543, CCSD:
2501, CBank-STR:8288, GenDB:AFl28887
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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