Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: infection due to Haemophilus influenzae [ICD11:
XN1P6 
];
infection due to Escherichia coli [ICD11:
XN6P4 ]
Publication DOI: 10.1002/anie.201301633Journal NLM ID: 0370543Publisher: Weinheim: Wiley-VCH
Correspondence: M. Caroff <martine.caroff
u-psud.fr>; peter.seeberger
mpikg.mpg.de
Institutions: Prof. Dr. P. H. Seeberger Institute of Chemistry and Biochemistry Freie Universitt Berlin Arnimallee 22, 14195 Berlin, Germany
The sugar coat of 'Black Death' betrays it. The plague can be detected by monoclonal anti-carbohydrate antibodies. In a new technique, a plague-specific oligosaccharide antigen (see structure) is synthesized. With the help of lipopolysaccharide (LPS)-specific monoclonal antibodies (mAbs), the presence of the plague pathogen Yersinia pestis can then be detected in serum from patients by using a glycan microarray.
lipopolysaccharides, antibodies, Oligosaccharides, Yersinia pestis, pathogen detection
Structure type: oligomer
Location inside paper: p.S36, 8
Aglycon: 5-aminopentyl
Compound class: core oligosaccharide
Contained glycoepitopes: IEDB_130650,IEDB_140088,IEDB_2189047
Methods: 13C NMR, 1H NMR, SDS-PAGE, chemical methods, MALDI-TOF MS, serological methods, conjugation
Synthetic data: chemical
Comments, role: Heptose-Heptose-Kdo trisaccharide components from E-coli and Haemophilus influenzae B LPS
Related record ID(s): 29425, 29426, 29905
NCBI Taxonomy refs (TaxIDs): 727,
562Reference(s) to other database(s): GTC:G07682RX
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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